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EIF4E: eukaryotic translation initiation factor 4E

1 protein, 57 patents, 0 drugs, 0 trials, 6,074 NIH grants and 11,045 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEIF4EHGNC
Nameeukaryotic translation initiation factor 4EHGNC
NCBI Gene ID1977NCBI Gene
HGNC IDHGNC:3287HGNC
EnsemblENSG00000151247NCBI Gene
AliasesAUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4ENCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P06730Eukaryotic translation initiation factor 4E21745Ensembl, GeneID, HGNCUniProt

Patents 57

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1912319P06730Espacenet
JP 2025517970 A2025-06-1212319P06730Espacenet
EP 4519435 A22025-03-1235P06730Espacenet
JP 2024123008 A2024-09-106103P06730Espacenet
JP 2024509742 A2024-03-05172P06730Espacenet
JP 2023123507 A2023-09-05316P06730Espacenet
US 11708396 B22023-07-252396P06730Espacenet
JP 2023522957 A2023-06-018P06730Espacenet
JP 2023514611 A2023-04-06137P06730Espacenet
US 11591576 B22023-02-28137P06730Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 6074

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant722,025NIH's project files
R01CA080728Oncogenic Impact of eIF4E-dependent RNA Export in Cancer462,025NIH's project files
P30CA008748Cancer Center Support Grant452,025NIH's project files
R01CA098571Molecular Mechanisms of eIF4E Mediated Transformation372,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center272,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)192,025NIH's project files
P30CA016058Cancer Center Support Grant182,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes162,025NIH's project files
R01GM056927Control of Translation in Herpesvirus Infected Cells - Resubmission - 1132,025NIH's project files
P01CA013106Targeting Transcription and Splicing in Cancer122,025NIH's project files

Papers 11045

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826912PubTator, text miningPubMed
42800523PubTator, text miningPubMed
42794724PubTator, text miningPubMed
42794618PubTator, text miningPubMed
42773810PubTator, text miningPubMed
42741995PubTator, text miningPubMed
42732692PubTator, text miningPubMed
42725432PubTator, text miningPubMed
42714812PubTator, text miningPubMed
42689995PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license