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Gene · 1982

EIF4G2: eukaryotic translation initiation factor 4 gamma 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EIF4G2: eukaryotic translation initiation factor 4 gamma 2. Genes, record 1982. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1982

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Gene

Symbol
EIF4G2
HGNC
Name
eukaryotic translation initiation factor 4 gamma 2
HGNC
NCBI Gene ID
1982
NCBI Gene
HGNC ID
HGNC:3297
HGNC
Ensembl
ENSG00000110321
NCBI Gene
Aliases
AAG1, DAP5, NAT1, P97, p97
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P78344Eukaryotic translation initiation factor 4 gamma 29074Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2020043864 A12020-03-051186P78344Espacenet
EP 3585909 A12020-01-01236P78344Espacenet
KR 1020190126812 A2019-11-12236P78344Espacenet
WO 2015174544 A2015-11-1952P78344Espacenet
US 8586006 B22013-11-19471P78344Espacenet
EP 2607900 A12013-06-261356P78344Espacenet
WO 2011027308 A12011-03-10224P78344Espacenet
WO 2011027310 A12011-03-10224P78344Espacenet
WO 2011027311 A22011-03-10224P78344Espacenet
US 7867724 B22011-01-115P78344Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants941

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEIF4G2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant62025
P30CA008748Cancer Center Support Grant42025
K12CA215110YALE CANCER CENTER CALABRESI IMMUNO-ONCOLOGY TRAINING PROGRAM32025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 532025
P30CA021765Cancer Center Support Grant (CCSG)32025
P30CA030199Cancer Center Support Grant (CCSG)32025
P30ES006694Southwest Environmental Health Sciences Center32025
R01CA142861Renewal: HPV and the DNA Damage Response32025
R01HL164584uORF-mediated Translational Control of Cardiac Transcription Factor Expression32025
R35GM119735Regulatory roles for the Integrator complex and circular RNAs32025

1 to 10 of 941Source NIH's project files

See all 941 nih grants

Papers1,382

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Biosynthesis of Complex Phenazines Involves Dimerization and Amination Catalyzed by a Versatile Nuclear Transport Factor 2‑like Superfamily Protein.JACS Au202642819288PubTator, text miningPubMed
Local translation couples synaptic activity to mitochondrial adaptation in dendrites.bioRxiv202642779733PubTator, text miningPubMed
Splicing dependency between EIF4G2 introns is mediated by exon definition and relies on a downstream splicing event.J Biol Chem202642364809PubTator, text miningPubMed
The role of RNA modifications in cancer translational control.RNA Biol202642343618PubTator, text miningPubMed
eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression.Cancer Res202642202060PubTator, text miningPubMed
Translation factor eIF4G2 directs CD8+ T cell lineage commitment by selectively enabling the IL-7 receptor response.iScience202641940334PubTator, text miningPubMed
A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia.Nat Commun202641916975PubTator, text miningPubMed
eIF4G2-dependent translation restrains pancreatic cancer progression.bioRxiv202641890118PubTator, text miningPubMed
PRRC2A, PRRC2B and PRRC2C are Stress Granule Proteins that Promote Translation Through Association with the eIF3 complex.bioRxiv202641808986PubTator, text miningPubMed
RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets.MedComm (2020)202641756253PubTator, text miningPubMed

1 to 10 of 1,382

See all 1,382 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1982

GET https://conductscience.org/api/genes/v1/1982/patents