Gene · 1984
EIF5A: eukaryotic translation initiation factor 5A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. EIF5A: eukaryotic translation initiation factor 5A. Genes, record 1984. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1984
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P63241 | Eukaryotic translation initiation factor 5A-1 | 154 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents193
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 45587 | P63241 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 45589 | P63241 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 45590 | P63241 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6222 | P63241 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5088 | P63241 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6222 | P63241 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 5088 | P63241 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 28924 | P63241 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 28925 | P63241 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 28926 | P63241 | Espacenet |
1 to 10 of 193
See all 193 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,233
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | EIF5A papers | Newest fiscal year |
|---|---|---|---|
| R01DK060581 | Transcriptional and Translational Mechanisms Governing Beta Cell Function | 21 | 2025 |
| ZIAHD001010 | Mechanism and Regulation of Eukaryotic Protein Synthesis | 14 | 2025 |
| P30DK020595 | Diabetes Research and Training Center | 8 | 2025 |
| R01DK124906 | Polyamines and Hypusine in Type 1 Diabetes Pathogenesis | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| I01CX002171 | "Dysregulated Polyamine Metabolism in H. pylori-associated Gastric Inflammation and Disease Progression" | 6 | 2025 |
| P01CA116087 | H. pylori-induced Inflammation and Gastric Cancer | 6 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 6 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 6 | 2025 |
1 to 10 of 1,233Source NIH's project files
See all 1,233 nih grantsPapers1,878
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles. | Elife | 2026 | 42689549 | PubTator, text mining | PubMed |
| Spermidine in Colorectal cancer: friend or foe? | Amino Acids | 2026 | 42684553 | PubTator, text mining | PubMed |
| The hypusine circuit: eIF5A at the crossroads of polyamine metabolism, malignant progression, and therapeutic vulnerability. | Biochim Biophys Acta Rev Cancer | 2026 | 42604705 | PubTator, text mining | PubMed |
| EBV-Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma. | Adv Sci (Weinh) | 2026 | 42603298 | PubTator, text mining | PubMed |
| Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review). | Int J Mol Med | 2026 | 42495772 | PubTator, text mining | PubMed |
| Exploring the Role of Hypusine Signaling in Vascular Smooth Muscle Cells for Mitigating Restenosis in Coronary Artery Disease. | Arterioscler Thromb Vasc Biol | 2026 | 42389790 | PubTator, text mining | PubMed |
| Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study. | Clin Epigenetics | 2026 | 42304432 | PubTator, text mining | PubMed |
| Regulation of EIF5A and hypusination by p53 determines colorectal cancer cell fitness. | Cancer Lett | 2026 | 42297232 | PubTator, text mining | PubMed |
| A gene therapy strategy for Deoxyhypusine Synthase (DHPS) syndrome. | Res Sq | 2026 | 42239796 | PubTator, text mining | PubMed |
| Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation. | Nat Commun | 2026 | 42098118 | PubTator, text mining | PubMed |
1 to 10 of 1,878
See all 1,878 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1984
GET https://conductscience.org/api/genes/v1/1984/patents?page=2