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Gene · 1984

EIF5A: eukaryotic translation initiation factor 5A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EIF5A: eukaryotic translation initiation factor 5A. Genes, record 1984. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1984

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Gene

Symbol
EIF5A
HGNC
Name
eukaryotic translation initiation factor 5A
HGNC
NCBI Gene ID
1984
NCBI Gene
HGNC ID
HGNC:3300
HGNC
Ensembl
ENSG00000132507
NCBI Gene
Aliases
EIF-5A, EIF5A1, FABAS, MGC104255, MGC99547, eIF-4D, eIF5AI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P63241Eukaryotic translation initiation factor 5A-11544Ensembl, GeneID, HGNC

Source UniProt

Patents193

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445587P63241Espacenet
JP 2026004568 A2026-01-1445589P63241Espacenet
JP 2026004568 A2026-01-1445590P63241Espacenet
EP 4650780 A22025-11-196222P63241Espacenet
EP 4641202 A22025-10-295088P63241Espacenet
JP 2025517970 A2025-06-126222P63241Espacenet
KR 1020250017231 A2025-02-045088P63241Espacenet
US 11446398 B22022-09-2028924P63241Espacenet
US 11446398 B22022-09-2028925P63241Espacenet
US 11446398 B22022-09-2028926P63241Espacenet

1 to 10 of 193

See all 193 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,233

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEIF5A papersNewest fiscal year
R01DK060581Transcriptional and Translational Mechanisms Governing Beta Cell Function212025
ZIAHD001010Mechanism and Regulation of Eukaryotic Protein Synthesis142025
P30DK020595Diabetes Research and Training Center82025
R01DK124906Polyamines and Hypusine in Type 1 Diabetes Pathogenesis82025
P30CA008748Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant72025
I01CX002171"Dysregulated Polyamine Metabolism in H. pylori-associated Gastric Inflammation and Disease Progression"62025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer62025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant62025
P30DK058404Molecular and Cellular Basis for Digestive Diseases62025

1 to 10 of 1,233Source NIH's project files

See all 1,233 nih grants

Papers1,878

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles.Elife202642689549PubTator, text miningPubMed
Spermidine in Colorectal cancer: friend or foe?Amino Acids202642684553PubTator, text miningPubMed
The hypusine circuit: eIF5A at the crossroads of polyamine metabolism, malignant progression, and therapeutic vulnerability.Biochim Biophys Acta Rev Cancer202642604705PubTator, text miningPubMed
EBV-Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma.Adv Sci (Weinh)202642603298PubTator, text miningPubMed
Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review).Int J Mol Med202642495772PubTator, text miningPubMed
Exploring the Role of Hypusine Signaling in Vascular Smooth Muscle Cells for Mitigating Restenosis in Coronary Artery Disease.Arterioscler Thromb Vasc Biol202642389790PubTator, text miningPubMed
Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study.Clin Epigenetics202642304432PubTator, text miningPubMed
Regulation of EIF5A and hypusination by p53 determines colorectal cancer cell fitness.Cancer Lett202642297232PubTator, text miningPubMed
A gene therapy strategy for Deoxyhypusine Synthase (DHPS) syndrome.Res Sq202642239796PubTator, text miningPubMed
Mitochondria serve as a holdout compartment for aggregation-prone proteins hindering efficient degradation.Nat Commun202642098118PubTator, text miningPubMed

1 to 10 of 1,878

See all 1,878 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1984

GET https://conductscience.org/api/genes/v1/1984/patents?page=2