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ELANE: elastase, neutrophil expressed

1 protein, 138 patents, 4 drugs, 64 trials, 5,483 NIH grants and 16,153 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolELANEHGNC
Nameelastase, neutrophil expressedHGNC
NCBI Gene ID1991NCBI Gene
HGNC IDHGNC:3309HGNC
EnsemblENSG00000197561NCBI Gene
AliasesELA2, GE, HLE, HNE, NE, PMN-E, SCN1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08246Neutrophil elastase26738Ensembl, GeneID, HGNCUniProt

Patents 138

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4802273 A12026-09-097P08246Espacenet
JP 2026513892 A2026-05-012P08246Espacenet
EP 4689095 A22026-02-112P08246Espacenet
JP 2026004568 A2026-01-1444832P08246Espacenet
JP 2026004568 A2026-01-1444833P08246Espacenet
US 12509511 B22025-12-3010P08246Espacenet
KR 1020250174635 A2025-12-122P08246Espacenet
EP 4650780 A22025-11-192225P08246Espacenet
JP 2025147176 A2025-10-064671P08246Espacenet
JP 2025147176 A2025-10-064672P08246Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
.ALPHA.1-PROTEINASE INHIBITOR HUMANCHEMBL4297879Leukocyte elastase inhibitorINHIBITORChEMBL
ALVELESTATCHEMBL3617964Leukocyte elastase inhibitorINHIBITORChEMBL
DEPELESTATCHEMBL2108025Leukocyte elastase inhibitorINHIBITORChEMBL
SIVELESTATCHEMBL76688Leukocyte elastase inhibitorINHIBITORChEMBL

Trials 64

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07555483.ALPHA.1-PROTEINASE INHIBITOR HUMANPHASE3ClinicalTrials.gov
NCT07214103SIVELESTATPHASE2ClinicalTrials.gov
NCT07196605SIVELESTATClinicalTrials.gov
NCT07125664.ALPHA.1-PROTEINASE INHIBITOR HUMANPHASE2ClinicalTrials.gov
NCT06381661SIVELESTATPHASE2ClinicalTrials.gov
NCT04799873.ALPHA.1-PROTEINASE INHIBITOR HUMANClinicalTrials.gov
NCT04675086.ALPHA.1-PROTEINASE INHIBITOR HUMANPHASE3ClinicalTrials.gov
NCT04547140.ALPHA.1-PROTEINASE INHIBITOR HUMANPHASE22023-03-22ClinicalTrials.gov
NCT04495101.ALPHA.1-PROTEINASE INHIBITOR HUMANPHASE2ClinicalTrials.gov
NCT04204252.ALPHA.1-PROTEINASE INHIBITOR HUMANPHASE3ClinicalTrials.gov

NIH grants 5483

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant452,025NIH's project files
ZIAAR041199Systemic Autoimmunity352,025NIH's project files
P30DK065988UNC Cystic Fibrosis Research and Translation Core Center222,025NIH's project files
P30DK089507Center for Cystic Fibrosis Translational Research in the Post-CFTR modulator Era202,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition202,025NIH's project files
T32GM008315Mechanisms of Trauma-Induced Coagulopathy172,025NIH's project files
P30DK072482UAB CF Research and Translation Core Center162,025NIH's project files
P30CA008748Cancer Center Support Grant132,025NIH's project files
T32AR007080Scientist Training in Rheumatology Research122,025NIH's project files
R01HL134846Purinergic modulation of the autoimmune vascular phenotype112,025NIH's project files

Papers 16153

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821483PubTator, text miningPubMed
42817075PubTator, text miningPubMed
42807352PubTator, text miningPubMed
42805959PubTator, text miningPubMed
42794705PubTator, text miningPubMed
42792218PubTator, text miningPubMed
42769765PubTator, text miningPubMed
42762810PubTator, text miningPubMed
42742850PubTator, text miningPubMed
42727792PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license