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A2M: alpha-2-macroglobulin

1 protein, 101 patents, 2 drugs, 0 trials, 3,773 NIH grants and 10,086 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolA2MHGNC
Namealpha-2-macroglobulinHGNC
NCBI Gene ID2NCBI Gene
HGNC IDHGNC:7HGNC
EnsemblENSG00000175899NCBI Gene
AliasesA2MD, CPAMD5, FWP007, S863-7NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01023Alpha-2-macroglobulin1,47413Ensembl, GeneID, HGNCUniProt

Patents 101

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4823630 A12026-10-2120P01023Espacenet
EP 4802273 A12026-09-0937P01023Espacenet
JP 2026513892 A2026-05-0122P01023Espacenet
EP 4689095 A22026-02-1122P01023Espacenet
JP 2026004568 A2026-01-1437152P01023Espacenet
KR 1020250174635 A2025-12-1222P01023Espacenet
EP 4650780 A22025-11-195526P01023Espacenet
EP 4641201 A22025-10-295140P01023Espacenet
JP 2025147176 A2025-10-065P01023Espacenet
JP 2025529142 A2025-09-045341P01023Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TECHNETIUM SUCCIMERCHEMBL2110572Alpha-2-macroglobulin binding agentBINDING AGENTChEMBL
TECHNETIUM TC 99M SUCCIMERCHEMBL1200797Alpha-2-macroglobulin binding agentBINDING AGENTChEMBL

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3773

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
T32GM008256Postdoctoral Training in Trauma and Burns162,025NIH's project files
T32GM008315Mechanisms of Trauma-Induced Coagulopathy152,025NIH's project files
P30CA008748Cancer Center Support Grant132,025NIH's project files
P30CA016672Cancer Center Support Grant122,025NIH's project files
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)122,025NIH's project files
ZIAAI001065India International Center for Excellence in Research102,025NIH's project files
P30CA006973Regional Oncology Research Center92,025NIH's project files
R01CA160254Serum Glyco-Markers of Early Hepatocellular Carcinoma Using a Mass Spec Approach92,025NIH's project files
P50CA092629SPORE in Prostate Cancer82,025NIH's project files
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study72,025NIH's project files

Papers 10086

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42797298PubTator, text miningPubMed
42745850PubTator, text miningPubMed
42737666PubTator, text miningPubMed
42710339PubTator, text miningPubMed
42669558PubTator, text miningPubMed
42663856PubTator, text miningPubMed
42661952PubTator, text miningPubMed
42643490PubTator, text miningPubMed
42638650PubTator, text miningPubMed
42633042PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license