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Gene · 200186

CRTC2: CREB regulated transcription coactivator 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CRTC2: CREB regulated transcription coactivator 2. Genes, record 200186. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/200186

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Gene

Symbol
CRTC2
HGNC
Name
CREB regulated transcription coactivator 2
HGNC
NCBI Gene ID
200186
NCBI Gene
HGNC ID
HGNC:27301
HGNC
Ensembl
ENSG00000160741
NCBI Gene
Aliases
TORC-2, TORC2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q53ET0CREB-regulated transcription coactivator 26931Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442363Q53ET0Espacenet
EP 4650780 A22025-11-198482Q53ET0Espacenet
EP 4641201 A22025-10-298652Q53ET0Espacenet
JP 2025517969 A2025-06-128652Q53ET0Espacenet
JP 2025517970 A2025-06-128482Q53ET0Espacenet
US 12195490 B22025-01-145Q53ET0Espacenet
JP 2023512082 A2023-03-235Q53ET0Espacenet
US 11446398 B22022-09-2020188Q53ET0Espacenet
JP 2022524081 A2022-04-27123159Q53ET0Espacenet
US 11078247 B22021-08-032608Q53ET0Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,519

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCRTC2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes92025
P30CA008748Cancer Center Support Grant92025
P30CA014195Cancer Center Support Grant (CCSG)82025
P30CA006973Regional Oncology Research Center72025
R35GM118177Excitable Networks in Directed Cell Migration72025
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)62025
ZIADK075040SIGNALING PATHWAYS IN CONTROL OF GROWTH AND DEVELOPMENT62025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
P30CA068485Cancer Center Support Grant42025

1 to 10 of 1,519Source NIH's project files

See all 1,519 nih grants

Papers1,653

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Lycopene Alleviates T-2 Toxin-Induced Testosterone Synthesis Disorder by Inhibiting ROS/p38/TORC2/CREB Axis.Antioxidants (Basel)202642792100PubTator, text miningPubMed
Potential Shared Immunometabolic Signatures Between Familial Hypercholesterolemia and Major Depressive Disorder: Integrative Transcriptomic Analysis, Mendelian Randomization, and Clinical Validation.Int J Mol Sci202642737434PubTator, text miningPubMed
CRTC, not phosphorylated CREB1, drives cAMP-induced transcription across diverse cell types.bioRxiv202642619677PubTator, text miningPubMed
Metformin's disruption of gluconeogenesis in type 2 diabetes impairments of the cori and alanine cycles as hidden drivers of metabolic waste accumulation, NF-κBHIF-1α-mediated low-grade inflammation, and multisystem dysfunction.
Probl Endokrinol (Mosk)202642545322PubTator, text miningPubMed
Occurrence and toxicity mechanisms of hexafluoropropylene oxide dimer acid (HPFO-DA, GenX) in aquatic species.Environ Sci Process Impacts202642429221PubTator, text miningPubMed
LKB1 inactivation elicits an NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer.Cell Rep202642234565PubTator, text miningPubMed
DNA-PK-mediated CRTC2 phosphorylation promotes NHEJ and suppresses antitumor immunity via relocation to repair complexes.Nat Commun202642151152PubTator, text miningPubMed
Uncoupling of nutrient sensing and cell size control by specific defects in ceramide structure.Biol Open202642093330PubTator, text miningPubMed
Targeting CRTC2 reverses STK11 mutant NSCLC tumor resistance to immunotherapy.Proc Natl Acad Sci U S A202642018410PubTator, text miningPubMed
Exploitation of CREB signaling by HTLV-1 and BLV: A central axis in viral persistence and leukemogenesis.Med Oncol202641774334PubTator, text miningPubMed

1 to 10 of 1,653

See all 1,653 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/200186

GET https://conductscience.org/api/genes/v1/200186/patents?page=2