Gene · 200186
CRTC2: CREB regulated transcription coactivator 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CRTC2: CREB regulated transcription coactivator 2. Genes, record 200186. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/200186
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q53ET0 | CREB-regulated transcription coactivator 2 | 693 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 42363 | Q53ET0 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8482 | Q53ET0 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8652 | Q53ET0 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8652 | Q53ET0 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8482 | Q53ET0 | Espacenet |
| US 12195490 B2 | 2025-01-14 | 5 | Q53ET0 | Espacenet |
| JP 2023512082 A | 2023-03-23 | 5 | Q53ET0 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 20188 | Q53ET0 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 123159 | Q53ET0 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 2608 | Q53ET0 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,519
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CRTC2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 8 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 7 | 2025 |
| R35GM118177 | Excitable Networks in Directed Cell Migration | 7 | 2025 |
| P50CA101942 | DF/HCC Kidney Cancer SPORE (supplement) | 6 | 2025 |
| ZIADK075040 | SIGNALING PATHWAYS IN CONTROL OF GROWTH AND DEVELOPMENT | 6 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,519Source NIH's project files
See all 1,519 nih grantsPapers1,653
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Lycopene Alleviates T-2 Toxin-Induced Testosterone Synthesis Disorder by Inhibiting ROS/p38/TORC2/CREB Axis. | Antioxidants (Basel) | 2026 | 42792100 | PubTator, text mining | PubMed |
| Potential Shared Immunometabolic Signatures Between Familial Hypercholesterolemia and Major Depressive Disorder: Integrative Transcriptomic Analysis, Mendelian Randomization, and Clinical Validation. | Int J Mol Sci | 2026 | 42737434 | PubTator, text mining | PubMed |
| CRTC, not phosphorylated CREB1, drives cAMP-induced transcription across diverse cell types. | bioRxiv | 2026 | 42619677 | PubTator, text mining | PubMed |
Metformin's disruption of gluconeogenesis in type 2 diabetes impairments of the cori and alanine cycles as hidden drivers of metabolic waste accumulation, NF-κBHIF-1α-mediated low-grade inflammation, and multisystem dysfunction. | Probl Endokrinol (Mosk) | 2026 | 42545322 | PubTator, text mining | PubMed |
| Occurrence and toxicity mechanisms of hexafluoropropylene oxide dimer acid (HPFO-DA, GenX) in aquatic species. | Environ Sci Process Impacts | 2026 | 42429221 | PubTator, text mining | PubMed |
| LKB1 inactivation elicits an NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer. | Cell Rep | 2026 | 42234565 | PubTator, text mining | PubMed |
| DNA-PK-mediated CRTC2 phosphorylation promotes NHEJ and suppresses antitumor immunity via relocation to repair complexes. | Nat Commun | 2026 | 42151152 | PubTator, text mining | PubMed |
| Uncoupling of nutrient sensing and cell size control by specific defects in ceramide structure. | Biol Open | 2026 | 42093330 | PubTator, text mining | PubMed |
| Targeting CRTC2 reverses STK11 mutant NSCLC tumor resistance to immunotherapy. | Proc Natl Acad Sci U S A | 2026 | 42018410 | PubTator, text mining | PubMed |
| Exploitation of CREB signaling by HTLV-1 and BLV: A central axis in viral persistence and leukemogenesis. | Med Oncol | 2026 | 41774334 | PubTator, text mining | PubMed |
1 to 10 of 1,653
See all 1,653 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/200186
GET https://conductscience.org/api/genes/v1/200186/patents?page=2