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Gene · 200424

TET3: tet methylcytosine dioxygenase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TET3: tet methylcytosine dioxygenase 3. Genes, record 200424. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/200424

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Gene

Symbol
TET3
HGNC
Name
tet methylcytosine dioxygenase 3
HGNC
NCBI Gene ID
200424
NCBI Gene
HGNC ID
HGNC:28313
HGNC
Ensembl
ENSG00000187605
NCBI Gene
Aliases
BEFAHRS, MGC22014, hCG_40738
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43151Methylcytosine dioxygenase TET31,7952Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025254779 A12025-12-113O43151Espacenet
WO 2025224162 A12025-10-303O43151Espacenet
EP 4640827 A12025-10-293O43151Espacenet
EP 4641201 A22025-10-2913053O43151Espacenet
JP 2025517969 A2025-06-1213053O43151Espacenet
WO 2024256581 A12024-12-1947O43151Espacenet
KR 1020240011120 A2024-01-25601O43151Espacenet
JP 2024501383 A2024-01-11625O43151Espacenet
JP 2023529844 A2023-07-1286O43151Espacenet
KR 1020230021081 A2023-02-133O43151Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,762

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTET3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant192025
P30CA016672Cancer Center Support Grant142025
R01HG006827Labeling and sequencing of 5hmC and 5mC in DNA-Renewal122025
R35CA210043The TET-DNMT-ASXL1-OGT axis: relevance to clonal hematopoiesis, heterochromatin integrity and cancer92025
UL1TR001863Yale Clinical and Translational Science Award72025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA016086Cancer Center Support Grant52025
P30CA023168Cancer Center Support Grant52025
P30CA021765Cancer Center Support Grant (CCSG)42025
P30CA033572Cancer Center Support Grant42025

1 to 10 of 1,762Source NIH's project files

See all 1,762 nih grants

Papers2,594

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TCR-mTORC1 signaling promotes epigenetic stabilization of Foxp3 expression in regulatory T cells via TET protein translation.Proc Natl Acad Sci U S A202642809396PubTator, text miningPubMed
Further delineation of 2p13.2-p11.2 deletion syndrome by optical genome mapping.Neurogenetics202642762249PubTator, text miningPubMed
Epigenetic alterations in rheumatoid arthritis: multilayer mechanisms and translational opportunities.Front Immunol202642746461PubTator, text miningPubMed
Elevated DNA 5-hydroxymethylation promotes chondrocyte differentiation via TET-mediated epigenetic downregulation of hTERT in human mesenchymal stem cells.Histochem Cell Biol202642680856PubTator, text miningPubMed
Validating raloxifene-mediated restoration of DNMT-TET epigenetic balance in breast and lung cancer.Cancer Treat Res Commun202642612286PubTator, text miningPubMed
Clinical Significance of SOX2 Promoter Methylation in Breast Cancer Prognosis.Cancer Control202642555815PubTator, text miningPubMed
Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3-CXCL8 Axis.Adv Sci (Weinh)202642531706PubTator, text miningPubMed
TET Enzymes as Epigenetic Integrators in Intestinal Immunity, Inflammation, and Disease.J Pers Med202642506101PubTator, text miningPubMed
Biomarkers for Diabetic Peripheral Artery Disease: An Integrated Review and Clinical Perspective.Diabetes Metab Res Rev202642402062PubTator, text miningPubMed
Increased TET3 expression associates with proinflammatory cytokines and reduced 5-hydroxymethylcytosine in periapical lesions.Clin Oral Investig202642377549PubTator, text miningPubMed

1 to 10 of 2,594

See all 2,594 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/200424

GET https://conductscience.org/api/genes/v1/200424/patents