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PIKFYVE: phosphoinositide kinase, FYVE-type zinc finger containing
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Gene · 200576

Papers1,790

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 1,790

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TitleJournalYearPMIDFound bySource
PI(3,5)P2 controls the signaling activity of class I PI3K.Sci Adv202642814813PubTator, text miningPubMed
JAK3 regulates PIP5K expression, promotes PIP2 generation and Ca2+ driven platelet activation in arterial thrombosis.Blood202642766692PubTator, text miningPubMed
Novel mutations of PIKFYVE identified in 322 sporadic cataract patients.Ophthalmic Genet202642717816PubTator, text miningPubMed
Targeting PIKfyve: Chemical Biology and Drug Discovery Insights.Chem Biol Drug Des202642681571PubTator, text miningPubMed
Ion transport as a determinant of membrane fusion and fission.Nat Struct Mol Biol202642618799PubTator, text miningPubMed
Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve.Bioorg Chem202642570378PubTator, text miningPubMed
Quantitative comparison of PI(3,5)P2 biosensors reveals SnxA is the most sensitive and unbiased.Mol Biol Cell202642555823PubTator, text miningPubMed
A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer.Cancer Cell202642546705PubTator, text miningPubMed
A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer.bioRxiv202642528528PubTator, text miningPubMed
PI4K and PIPK families in breast cancer: subtype-specific oncogenic mechanisms and precision therapeutic strategies.Mol Biol Rep202642455373PubTator, text miningPubMed
Beyond autophagic flux: selective autophagy adaptors and cargo prioritization in cardiac disease.Cardiol Plus202642369864PubTator, text miningPubMed
PIKfyve-specific Pt(II)-based targeted drug conjugate in treatment of ovarian cancer through multi-mode actions.J Inorg Biochem202642365687PubTator, text miningPubMed
PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.J Cell Biol202642360289PubTator, text miningPubMed
In Silico Systems Biology Approach for Prioritization of Candidate Genes Linked to Lipid Metabolism in the Context of Cardiovascular Disease Susceptibility in a Serbian Cohort.Curr Issues Mol Biol202642353617PubTator, text miningPubMed
Septins regulate kinase-inhibitor induced micron-scale vacuolation.Exp Cell Res202642276196PubTator, text miningPubMed
A PI(3,5)P2/CHMP4B axis on lysosomes is essential for microautophagic degradation of STING.Nat Commun202642203786PubTator, text miningPubMed
Synthesis, structure-activity relationships, and SARS-CoV-2 antiviral activity of 3,5-disubstituted isothiazolo[4,3-b]pyridines as PIKfyve inhibitors.Front Chem202642179838PubTator, text miningPubMed
IITZ01 attenuates fructose aggravated ulcerative colitis via prevention of macrophage activation and decrease in cytokine release via inhibition of PIP5 kinase.Int Immunopharmacol202642140165PubTator, text miningPubMed
Endolysosomal trafficking regulator SH-BC-893 inhibits coronavirus entry in vitro and in vivo.Sci Rep202642115643PubTator, text miningPubMed
How endosomal PIKfyve inhibition prevents viral membrane fusion and entry.Proc Natl Acad Sci U S A202642101989PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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