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Gene · 200576

PIKFYVE: phosphoinositide kinase, FYVE-type zinc finger containing

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PIKFYVE: phosphoinositide kinase, FYVE-type zinc finger containing. Genes, record 200576. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/200576

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Gene

Symbol
PIKFYVE
HGNC
Name
phosphoinositide kinase, FYVE-type zinc finger containing
HGNC
NCBI Gene ID
200576
NCBI Gene
HGNC ID
HGNC:23785
HGNC
Ensembl
ENSG00000115020
NCBI Gene
Aliases
FAB1, HEL37, KIAA0981, MGC40423, PIP5K, PIP5K3, ZFYVE29, p235
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y2I71-phosphatidylinositol 3-phosphate 5-kinase2,0981Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19375Q9Y2I7Espacenet
JP 2026004568 A2026-01-1457860Q9Y2I7Espacenet
EP 4650780 A22025-11-192344Q9Y2I7Espacenet
EP 4641201 A22025-10-291912Q9Y2I7Espacenet
JP 2025517969 A2025-06-121912Q9Y2I7Espacenet
JP 2025517970 A2025-06-122344Q9Y2I7Espacenet
WO 2024214081 A12024-10-17375Q9Y2I7Espacenet
JP 2022141755 A2022-09-29213Q9Y2I7Espacenet
US 11446398 B22022-09-2063131Q9Y2I7Espacenet
JP 2022524081 A2022-04-27166102Q9Y2I7Espacenet

1 to 10 of 15

See all 15 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APILIMODCHEMBL181441-phosphatidylinositol 3-phosphate 5-kinase inhibitorINHIBITORChEMBL
APILIMODCHEMBL42976431-phosphatidylinositol 3-phosphate 5-kinase inhibitorINHIBITORChEMBL
APILIMOD MESYLATECHEMBL60679971-phosphatidylinositol 3-phosphate 5-kinase inhibitorINHIBITORChEMBL

Trials10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05483322APILIMODClinicalTrials.gov
NCT05483322APILIMODClinicalTrials.gov
NCT05163886APILIMOD MESYLATEPHASE2ClinicalTrials.gov
NCT02594384APILIMOD MESYLATEPHASE12024-08-22ClinicalTrials.gov
NCT00642629APILIMOD MESYLATEPHASE2ClinicalTrials.gov
NCT00263237APILIMOD MESYLATEPHASE1ClinicalTrials.gov
NCT00250198APILIMOD MESYLATEPHASE2ClinicalTrials.gov
NCT00234741APILIMOD MESYLATEPHASE2ClinicalTrials.gov
NCT00138840APILIMOD MESYLATEPHASE2ClinicalTrials.gov
NCT00088062APILIMODPHASE1/PHASE2ClinicalTrials.gov

NIH grants1,374

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePIKFYVE papersNewest fiscal year
P30DK020572Michigan Diabetes Research Center (MDRC)102025
R35GM119412Directing Membrane Function with Inositol Lipids in Health and Disease92025
R35GM130386Cell Biology of Endosomal Escape92025
ZIAHD000196Phosphoinositide-calcium Signaling In Cell Regulation92025
U19AI135972SARS-CoV adaptations through a Systems Biology Lens (SYBIL)82025
P30CA030199Cancer Center Support Grant (CCSG)52025
P30DA018343Yale/NIDA Neuroproteomics Center52025
R01GM088790Functional architecture of intracellular Ca2+ signals52025
T32CA009054A Training Program for Interdisciplinary Cancer Research52025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes42025

1 to 10 of 1,374Source NIH's project files

See all 1,374 nih grants

Papers1,790

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PI(3,5)P2 controls the signaling activity of class I PI3K.Sci Adv202642814813PubTator, text miningPubMed
JAK3 regulates PIP5K expression, promotes PIP2 generation and Ca2+ driven platelet activation in arterial thrombosis.Blood202642766692PubTator, text miningPubMed
Novel mutations of PIKFYVE identified in 322 sporadic cataract patients.Ophthalmic Genet202642717816PubTator, text miningPubMed
Targeting PIKfyve: Chemical Biology and Drug Discovery Insights.Chem Biol Drug Des202642681571PubTator, text miningPubMed
Ion transport as a determinant of membrane fusion and fission.Nat Struct Mol Biol202642618799PubTator, text miningPubMed
Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve.Bioorg Chem202642570378PubTator, text miningPubMed
Quantitative comparison of PI(3,5)P2 biosensors reveals SnxA is the most sensitive and unbiased.Mol Biol Cell202642555823PubTator, text miningPubMed
A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer.Cancer Cell202642546705PubTator, text miningPubMed
A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer.bioRxiv202642528528PubTator, text miningPubMed
PI4K and PIPK families in breast cancer: subtype-specific oncogenic mechanisms and precision therapeutic strategies.Mol Biol Rep202642455373PubTator, text miningPubMed

1 to 10 of 1,790

See all 1,790 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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