ConductScience.org, home

Gene · 200909

HTR3D: 5-hydroxytryptamine receptor 3D

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. HTR3D: 5-hydroxytryptamine receptor 3D. Genes, record 200909. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/200909

On this page

Gene

Symbol
HTR3D
HGNC
Name
5-hydroxytryptamine receptor 3D
HGNC
NCBI Gene ID
200909
NCBI Gene
HGNC ID
HGNC:24004
HGNC
Ensembl
ENSG00000186090
NCBI Gene
Aliases
5HT3D
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q70Z445-hydroxytryptamine receptor 3D4540Ensembl, GeneID, HGNC

Source UniProt

Patents9

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435766Q70Z44Espacenet
JP 2025529142 A2025-09-042011Q70Z44Espacenet
US 12371689 B22025-07-292011Q70Z44Espacenet
JP 2025062604 A2025-04-14413Q70Z44Espacenet
US 11446398 B22022-09-20413Q70Z44Espacenet
JP 2022524081 A2022-04-27103384Q70Z44Espacenet
JP 2019054813 A2019-04-11216201Q70Z44Espacenet
JP 2017121241 A2017-07-13216201Q70Z44Espacenet
JP 2015516143 A2015-06-08216201Q70Z44Espacenet

Drugs15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
CLOTHIAPINECHEMBL304902Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
FACINICLINECHEMBL2151439Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
FACINICLINE HYDROCHLORIDECHEMBL5095032Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
MOSAPRIDECHEMBL60889Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
PUMOSETRAGCHEMBL1643880Serotonin 3 (5-HT3) receptor partial agonistPARTIAL AGONISTChEMBL
RAMOSETRONCHEMBL1643895Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
RAMOSETRON HYDROCHLORIDECHEMBL3181841Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL

1 to 10 of 15

See all 15 drugs

Trials67

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07152184AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06887621AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06585540AMISULPRIDEPHASE3ClinicalTrials.gov
NCT06581302AMISULPRIDEClinicalTrials.gov
NCT06166615RAMOSETRONPHASE2/PHASE3ClinicalTrials.gov
NCT06040944AMISULPRIDEClinicalTrials.gov
NCT05956600AMISULPRIDEClinicalTrials.gov
NCT05347199AMISULPRIDEPHASE1ClinicalTrials.gov
NCT04954365AMISULPRIDEClinicalTrials.gov
NCT04533724AMISULPRIDEEARLY_PHASE1ClinicalTrials.gov

1 to 10 of 67

See all 67 trials

NIH grants94

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTR3D papersNewest fiscal year
K12DA000167Clinician Scientist Training Program (CSTP)12025
P30CA016056Roswell Park Cancer Center Support Grant12025
P30CA076292Moffitt Cancer Center Support Grant12025
P30DK063491Diabetes Research Center (DRC)12025
R01EB023281FreeSurfer Development, Maintenance, and Hardening12025
T32CA090314Behavioral Oncology Education & Career Development12025
U01CA206110Transdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare Study12025
U24HG006673Systematic Exploration of the Human Interactome IV12025
R01NR018762Novel Biomarkers for Cancer-Related Fatigue: Integrating Metabolomics, Genomics and Behaviors12024
R01EY030851Integration of clinical measures and theoretical modeling to quantify sectorial specific changes in ocular structure, function, and hemodynamics12023

1 to 10 of 94Source NIH's project files

See all 94 nih grants

Papers122

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Predicted conformations of 5-HT3 receptor ion channels are modified by subunit D.Comput Struct Biotechnol J202540529179PubTator, text miningPubMed
Identification of Novel Genomic Variants in COVID-19 Patients Using Whole-Exome Sequencing: Exploring the Plausible Targets of Functional Genomics.Biochem Genet202539557769PubTator, text miningPubMed
Multi-step gene set analysis identified HTR3 family genes involving childhood acute lymphoblastic leukemia susceptibility.Arch Toxicol202539322821PubTator, text miningPubMed
Spatiotemporal expression patterns of anxiety disorder-associated genes.Transl Psychiatry202338092764PubTator, text miningPubMed
A randomized trial evaluating the association between related gene polymorphism and nausea and vomiting induced by cisplatin multi-day chemotherapy.BMC Med Genomics202337924126PubTator, text miningPubMed
5-HT3 Receptors on Mitochondria Influence Mitochondrial Function.Int J Mol Sci202337176009PubTator, text miningPubMed
Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer's disease.Neural Regen Res202336926728PubTator, text miningPubMed
Phylogenetic analyses of 5-hydroxytryptamine 3 (5-HT3) receptors in Metazoa.PLoS One202336857360PubTator, text miningPubMed
Association of HTR3B gene polymorphisms with depression and its executive dysfunction: a case-control study.BMC Psychiatry202336849934PubTator, text miningPubMed
Common susceptibility variants of KDR and IGF-1R are associated with poststroke depression in the Chinese population.Gen Psychiatr202336721715PubTator, text miningPubMed

1 to 10 of 122

See all 122 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/200909

GET https://conductscience.org/api/genes/v1/200909/drugs