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TIGIT: T cell immunoreceptor with Ig and ITIM domains

1 protein, 401 patents, 7 drugs, 113 trials, 3,367 NIH grants and 9,269 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTIGITHGNC
NameT cell immunoreceptor with Ig and ITIM domainsHGNC
NCBI Gene ID201633NCBI Gene
HGNC IDHGNC:26838HGNC
EnsemblENSG00000181847NCBI Gene
AliasesDKFZp667A205, FLJ39873, VSIG9, VSTM3, WUCAMNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q495A1T-cell immunoreceptor with Ig and ITIM domains24412Ensembl, GeneID, HGNCUniProt

Patents 401

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4831196 A22026-10-2819Q495A1Espacenet
EP 4806462 A22026-09-1638Q495A1Espacenet
US 12624087 B22026-05-1219Q495A1Espacenet
EP 4731682 A12026-04-2942Q495A1Espacenet
US 12612446 B22026-04-28460Q495A1Espacenet
EP 4724493 A12026-04-1523Q495A1Espacenet
EP 4724495 A12026-04-1523Q495A1Espacenet
JP 2026049003 A2026-03-171Q495A1Espacenet
JP 2026506893 A2026-02-27129Q495A1Espacenet
JP 2026028252 A2026-02-1930Q495A1Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASP-8374CHEMBL4297894T-cell immunoreceptor with Ig and ITIM domains antagonistANTAGONISTChEMBL
DOMVANALIMABCHEMBL4650392T-cell immunoreceptor with Ig and ITIM domains inhibitorINHIBITORChEMBL
ETIGILIMABCHEMBL4298205T-cell immunoreceptor with Ig and ITIM domains inhibitorINHIBITORChEMBL
IBI-939CHEMBL4650473T-cell immunoreceptor with Ig and ITIM domains inhibitorINHIBITORChEMBL
OCIPERLIMABCHEMBL4650411T-cell immunoreceptor with Ig and ITIM domains inhibitorINHIBITORChEMBL
TIRAGOLUMABCHEMBL4298050T-cell immunoreceptor with Ig and ITIM domains inhibitorINHIBITORChEMBL
VIBOSTOLIMABCHEMBL4297785T-cell immunoreceptor with Ig and ITIM domains antagonistANTAGONISTChEMBL

Trials 113

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07337447DOMVANALIMABPHASE2ClinicalTrials.gov
NCT07283848DOMVANALIMABPHASE2ClinicalTrials.gov
NCT07134556DOMVANALIMABPHASE2ClinicalTrials.gov
NCT07038915TIRAGOLUMABPHASE2ClinicalTrials.gov
NCT06790706DOMVANALIMABPHASE2ClinicalTrials.gov
NCT06784947TIRAGOLUMABPHASE2ClinicalTrials.gov
NCT06762808TIRAGOLUMABPHASE2ClinicalTrials.gov
NCT06727565DOMVANALIMABPHASE2ClinicalTrials.gov
NCT06603818TIRAGOLUMABPHASE2ClinicalTrials.gov
NCT06395090VIBOSTOLIMABPHASE1/PHASE2ClinicalTrials.gov

NIH grants 3367

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant802,025NIH's project files
P30CA016672Cancer Center Support Grant492,025NIH's project files
P01AI039671Costimulatory Mechanisms of Autoimmunity352,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award342,025NIH's project files
P30CA047904Cancer Center Support Grant312,025NIH's project files
P01AI108545Synergies among inhibitory receptors in tolerance and disease192,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies192,025NIH's project files
P30CA006973Regional Oncology Research Center192,025NIH's project files
P50CA121974Yale SPORE in Skin Cancer182,025NIH's project files
P51OD011132Emory National Primate Research Center182,025NIH's project files

Papers 9269

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823731PubTator, text miningPubMed
42819567PubTator, text miningPubMed
42818080PubTator, text miningPubMed
42816994PubTator, text miningPubMed
42814600PubTator, text miningPubMed
42814321PubTator, text miningPubMed
42810560PubTator, text miningPubMed
42805115PubTator, text miningPubMed
42800812PubTator, text miningPubMed
42798509PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license