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Gene · 2018

EMX2: empty spiracles homeobox 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EMX2: empty spiracles homeobox 2. Genes, record 2018. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2018

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Gene

Symbol
EMX2
HGNC
Name
empty spiracles homeobox 2
HGNC
NCBI Gene ID
2018
NCBI Gene
HGNC ID
HGNC:3341
HGNC
Ensembl
ENSG00000170370
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q04743Homeobox protein EMX22520Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444928Q04743Espacenet
EP 4650780 A22025-11-1916707Q04743Espacenet
JP 2025147176 A2025-10-0614932Q04743Espacenet
JP 2025517970 A2025-06-1216707Q04743Espacenet
JP 2025028160 A2025-02-2814932Q04743Espacenet
KR 1020250010750 A2025-01-2114932Q04743Espacenet
JP 2024109657 A2024-08-1414771Q04743Espacenet
JP 2024519218 A2024-05-09112Q04743Espacenet
KR 1020240005837 A2024-01-1269Q04743Espacenet
US 11446398 B22022-09-2027185Q04743Espacenet

1 to 10 of 25

See all 25 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants862

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEMX2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant42025
R24HD000836Laboratory of Developmental Biology32025
R37NS035129Human Epilepsy Genetics - Mosaic Mutations in Focal Epilepsy32025
UL1TR001881UCLA Clinical and Translational Science Institute32025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN22025
P30CA016672Cancer Center Support Grant22025
P30ES010126UNC Center for Environmental Health and Susceptibility22025
R01CA098571Molecular Mechanisms of eIF4E Mediated Transformation22025
R01CA159859Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma22025
R01DC015242Hair Cell Polarization and Sensory Bundle Development22025

1 to 10 of 862Source NIH's project files

See all 862 nih grants

Papers900

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Functional convergence of regulatory regions provides vital insights into mammalian gliding adaptation.Sci China Life Sci202642714797PubTator, text miningPubMed
Terminal 4q duplication and extended 10q deletion in a preterm infant with linear growth restriction: transcriptomic evidence of disrupted developmental and metabolic pathways.Front Pediatr202642395604PubTator, text miningPubMed
Establishing Area-Specific Brain Organoids Through Transcription Factor-Mediated Patterning.Biology (Basel)202641892247PubTator, text miningPubMed
Exploring roles of neuroglobin in oxygen homeostasis and neurodevelopment based on human cerebral organoid models.iScience202641797899PubTator, text miningPubMed
De novo rare EMX2 variants lead to idiopathic hypogonadotropic hypogonadism.Genet Med202641765865PubTator, text miningPubMed
Functional Validation of a Novel <italic>PBX1</italic> Missense Variant in a 46,XY Girl.Sex Dev202641746858PubTator, text miningPubMed
An in vivo and in vitro spatiotemporal profile of human midbrain development.Nat Commun202641633979PubTator, text miningPubMed
A developmentally regulated long-range enhancer-promoter contact mediates human neural development.bioRxiv202641573925PubTator, text miningPubMed
Abnormal PLK2 expression is associated with specific subtypes and may help risk stratification in acute myeloid leukemia.Discov Oncol202641530586PubTator, text miningPubMed
Missense variants in homeobox domain of PBX1 cause coracoclavicular ankylosis.Eur J Hum Genet202641162587PubTator, text miningPubMed

1 to 10 of 900

See all 900 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2018

GET https://conductscience.org/api/genes/v1/2018/patents?page=2