Gene · 2021
ENDOG: endonuclease G
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ENDOG: endonuclease G. Genes, record 2021. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2021
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14249 | Endonuclease G, mitochondrial | 297 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents28
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 44934 | Q14249 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 9140 | Q14249 | Espacenet |
| WO 2025217591 A1 | 2025-10-16 | 52 | Q14249 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 4750 | Q14249 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6260 | Q14249 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6260 | Q14249 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9140 | Q14249 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 4750 | Q14249 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 4750 | Q14249 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 4757 | Q14249 | Espacenet |
1 to 10 of 28
See all 28 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants944
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ENDOG papers | Newest fiscal year |
|---|---|---|---|
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 4 | 2025 |
| R01CA073764 | FEN1-mediated Okazaki fragment maturation and its deficiency in cancer | 3 | 2025 |
| R01DC009222 | Molecular mechanism in noise-induced hearing loss | 3 | 2025 |
| R01DK125465 | The Immune Response After Drug Induced Hepatotoxicity | 3 | 2025 |
| R35GM118188 | Fundamental mechanisms of paternal mitochondrial eliminationand radiation-induced bystander effects | 3 | 2025 |
| ZIANS002859 | Targeting Protein Aggregates for Autophagosomal Degradation | 3 | 2025 |
| P20GM103429 | Partnerships for Biomedical Research in Arkansas | 2 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 2 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 2 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 2 | 2025 |
1 to 10 of 944Source NIH's project files
See all 944 nih grantsPapers1,886
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of Endonuclease G binding protein using a method which specifically isolates binding partners within subcellular compartments. | Mol Cell Proteomics | 2026 | 42815854 | PubTator, text mining | PubMed |
| Sublethal Caspase-8 Activation Drives Radiation-Induced Genetic Instability and Oncogenic Transformation Through Endonuclease G and Non-Canonical NF-κB Signaling. | Int J Mol Sci | 2026 | 42653401 | PubTator, text mining | PubMed |
| The Marine Triterpene Stellettin B Triggers Mitochondrial-to-Nuclear Translocation of AIF/EndoG and Reverses Epithelial-Mesenchymal Transition to Inhibit Oral Cancer Progression. | Int J Med Sci | 2026 | 42524632 | PubTator, text mining | PubMed |
Newly synthesized (E)-4-(2-chloro-1-(2-chloro-benzyl)-1H-indol-3-yl)but-3-en-2-one (SBA) induces apoptotic cell death through Fas-FasL and mitochondria-mediated pathways in human oral carcinoma SCC-4 cells. | Biosci Biotechnol Biochem | 2026 | 42518252 | PubTator, text mining | PubMed |
| Identification and validation of biomarkers associated with mitochondria and glycometabolism in gestational diabetes mellitus. | Sci Rep | 2026 | 42374095 | PubTator, text mining | PubMed |
| Resveratrol isomers with opposing activities target endonuclease G to modulate neurodegeneration and mitochondrial elimination. | Proc Natl Acad Sci U S A | 2026 | 42296341 | PubTator, text mining | PubMed |
| Single-Nucleotide Polymorphisms in Genes Associated with Mitochondrial and DNA Damage Response Modulate the Risk of Non-Alcoholic Fatty Liver Disease in Humans. | Int J Mol Sci | 2026 | 42278383 | PubTator, text mining | PubMed |
| Harpagide attenuates cerebral ischemic injury by modulating mitochondrial calcium homeostasis associated with the AMPK-MCU axis. | Sci Rep | 2026 | 42225680 | PubTator, text mining | PubMed |
| An engineered viral RNA degrader on mitochondrial surface that mitigates RNA virus infection. | Nat Commun | 2026 | 42156374 | PubTator, text mining | PubMed |
| Discovery of an Endonuclease G-inhibitory Ku80-peptide protecting against leukemogenic rearrangements at the MLL breakpoint cluster. | Nat Commun | 2026 | 41991928 | PubTator, text mining | PubMed |
1 to 10 of 1,886
See all 1,886 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2021
GET https://conductscience.org/api/genes/v1/2021/patents?page=2