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Gene · 2021

ENDOG: endonuclease G

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ENDOG: endonuclease G. Genes, record 2021. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2021

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Gene

Symbol
ENDOG
HGNC
Name
endonuclease G
HGNC
NCBI Gene ID
2021
NCBI Gene
HGNC ID
HGNC:3346
HGNC
Ensembl
ENSG00000167136
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14249Endonuclease G, mitochondrial2972Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444934Q14249Espacenet
EP 4650780 A22025-11-199140Q14249Espacenet
WO 2025217591 A12025-10-1652Q14249Espacenet
JP 2025147176 A2025-10-064750Q14249Espacenet
JP 2025529142 A2025-09-046260Q14249Espacenet
US 12371689 B22025-07-296260Q14249Espacenet
JP 2025517970 A2025-06-129140Q14249Espacenet
JP 2025028160 A2025-02-284750Q14249Espacenet
KR 1020250010750 A2025-01-214750Q14249Espacenet
JP 2024109657 A2024-08-144757Q14249Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants944

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleENDOG papersNewest fiscal year
P30AG028740University of Florida Older Americans Independence Center (OAIC)42025
R01CA073764FEN1-mediated Okazaki fragment maturation and its deficiency in cancer32025
R01DC009222Molecular mechanism in noise-induced hearing loss32025
R01DK125465The Immune Response After Drug Induced Hepatotoxicity32025
R35GM118188Fundamental mechanisms of paternal mitochondrial eliminationand radiation-induced bystander effects32025
ZIANS002859Targeting Protein Aggregates for Autophagosomal Degradation32025
P20GM103429Partnerships for Biomedical Research in Arkansas22025
P30CA016056Roswell Park Cancer Center Support Grant22025
P30CA021765Cancer Center Support Grant (CCSG)22025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)22025

1 to 10 of 944Source NIH's project files

See all 944 nih grants

Papers1,886

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of Endonuclease G binding protein using a method which specifically isolates binding partners within subcellular compartments.Mol Cell Proteomics202642815854PubTator, text miningPubMed
Sublethal Caspase-8 Activation Drives Radiation-Induced Genetic Instability and Oncogenic Transformation Through Endonuclease G and Non-Canonical NF-κB Signaling.Int J Mol Sci202642653401PubTator, text miningPubMed
The Marine Triterpene Stellettin B Triggers Mitochondrial-to-Nuclear Translocation of AIF/EndoG and Reverses Epithelial-Mesenchymal Transition to Inhibit Oral Cancer Progression.Int J Med Sci202642524632PubTator, text miningPubMed
Newly synthesized (E)-4-(2-chloro-1-(2-chloro-benzyl)-1H-indol-3-yl)but-3-en-2-one (SBA) induces apoptotic cell death through Fas-FasL and mitochondria-mediated pathways in human oral carcinoma SCC-4 cells.
Biosci Biotechnol Biochem202642518252PubTator, text miningPubMed
Identification and validation of biomarkers associated with mitochondria and glycometabolism in gestational diabetes mellitus.Sci Rep202642374095PubTator, text miningPubMed
Resveratrol isomers with opposing activities target endonuclease G to modulate neurodegeneration and mitochondrial elimination.Proc Natl Acad Sci U S A202642296341PubTator, text miningPubMed
Single-Nucleotide Polymorphisms in Genes Associated with Mitochondrial and DNA Damage Response Modulate the Risk of Non-Alcoholic Fatty Liver Disease in Humans.Int J Mol Sci202642278383PubTator, text miningPubMed
Harpagide attenuates cerebral ischemic injury by modulating mitochondrial calcium homeostasis associated with the AMPK-MCU axis.Sci Rep202642225680PubTator, text miningPubMed
An engineered viral RNA degrader on mitochondrial surface that mitigates RNA virus infection.Nat Commun202642156374PubTator, text miningPubMed
Discovery of an Endonuclease G-inhibitory Ku80-peptide protecting against leukemogenic rearrangements at the MLL breakpoint cluster.Nat Commun202641991928PubTator, text miningPubMed

1 to 10 of 1,886

See all 1,886 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2021

GET https://conductscience.org/api/genes/v1/2021/patents?page=2