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ENG: endoglin

1 protein, 101 patents, 1 drug, 25 trials, 3,477 NIH grants and 7,706 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolENGHGNC
NameendoglinHGNC
NCBI Gene ID2022NCBI Gene
HGNC IDHGNC:3349HGNC
EnsemblENSG00000106991NCBI Gene
AliasesCD105, END, HHT1, ORW, ORW1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P17813Endoglin6583Ensembl, GeneID, HGNCUniProt

Patents 101

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026174137 A12026-08-2075P17813Espacenet
JP 2026027383 A2026-02-1831P17813Espacenet
EP 4650780 A22025-11-199267P17813Espacenet
EP 4641201 A22025-10-299503P17813Espacenet
JP 2025529142 A2025-09-041393P17813Espacenet
US 12371689 B22025-07-291393P17813Espacenet
JP 2025517969 A2025-06-129503P17813Espacenet
JP 2025517970 A2025-06-129267P17813Espacenet
JP 2025087789 A2025-06-107P17813Espacenet
EP 4491229 A22025-01-1569P17813Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CAROTUXIMABCHEMBL2109321Endoglin inhibitorINHIBITORChEMBL

Trials 25

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05534646CAROTUXIMABPHASE2ClinicalTrials.gov
NCT05401110CAROTUXIMABPHASE1ClinicalTrials.gov
NCT03780010CAROTUXIMABPHASE12019-10-28ClinicalTrials.gov
NCT03418324CAROTUXIMABPHASE22020-12-30ClinicalTrials.gov
NCT03211234CAROTUXIMABPHASE22021-07-13ClinicalTrials.gov
NCT03181308CAROTUXIMABPHASE12020-06-24ClinicalTrials.gov
NCT02979899CAROTUXIMABPHASE32020-05-12ClinicalTrials.gov
NCT02664961CAROTUXIMABPHASE22019-06-04ClinicalTrials.gov
NCT02560779CAROTUXIMABPHASE1/PHASE22020-07-17ClinicalTrials.gov
NCT02555306CAROTUXIMABPHASE1/PHASE22020-01-14ClinicalTrials.gov

NIH grants 3477

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition412,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support252,025NIH's project files
P30CA016672Cancer Center Support Grant232,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award202,025NIH's project files
P30CA008748Cancer Center Support Grant172,025NIH's project files
T32HL105324Hypertension and Cardiorenal Research Training Program142,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant132,025NIH's project files
P20GM121334Mississippi Center of Excellence in Perinatal Research, Phase 292,025NIH's project files
T32CA009206UW Radiological Sciences Training Program92,025NIH's project files
P30CA006973Regional Oncology Research Center82,025NIH's project files

Papers 7706

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820305PubTator, text miningPubMed
42814899PubTator, text miningPubMed
42793006PubTator, text miningPubMed
42792663PubTator, text miningPubMed
42778431PubTator, text miningPubMed
42776922PubTator, text miningPubMed
42772024PubTator, text miningPubMed
42770272PubTator, text miningPubMed
42760995PubTator, text miningPubMed
42752296PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license