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Gene · 2043

EPHA4: EPH receptor A4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EPHA4: EPH receptor A4. Genes, record 2043. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2043

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Gene

Symbol
EPHA4
HGNC
Name
EPH receptor A4
HGNC
NCBI Gene ID
2043
NCBI Gene
HGNC ID
HGNC:3388
HGNC
Ensembl
ENSG00000116106
NCBI Gene
Aliases
EK8, HEK8, Hek8, SEK, TYRO1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P54764Ephrin type-A receptor 498617Ensembl, GeneID, HGNC

Source UniProt

Patents178

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025259600 A22025-12-1837P54764Espacenet
EP 4650780 A22025-11-193135P54764Espacenet
EP 4641201 A22025-10-292696P54764Espacenet
EP 4641202 A22025-10-29157P54764Espacenet
EP 4641203 A22025-10-29104P54764Espacenet
JP 2025147176 A2025-10-064814P54764Espacenet
JP 2025147176 A2025-10-064815P54764Espacenet
JP 2025529142 A2025-09-041415P54764Espacenet
JP 2025529142 A2025-09-046273P54764Espacenet
US 12371689 B22025-07-291415P54764Espacenet

1 to 10 of 178

See all 178 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
VANDETANIBCHEMBL24828Ephrin receptor inhibitorINHIBITOR

Source ChEMBL

Trials97

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06482086VANDETANIBPHASE2ClinicalTrials.gov
NCT04211337VANDETANIBPHASE32024-06-13ClinicalTrials.gov
NCT03630120VANDETANIBPHASE22021-01-22ClinicalTrials.gov
NCT03291379VANDETANIBEARLY_PHASE12021-02-03ClinicalTrials.gov
NCT02638428VANDETANIBPHASE2ClinicalTrials.gov
NCT02530411VANDETANIBPHASE2ClinicalTrials.gov
NCT02495103VANDETANIBPHASE1/PHASE22021-01-26ClinicalTrials.gov
NCT02299999VANDETANIBPHASE2ClinicalTrials.gov
NCT02117167VANDETANIBPHASE2ClinicalTrials.gov
NCT02109250VANDETANIBClinicalTrials.gov

1 to 10 of 97

See all 97 trials

NIH grants1,711

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEPHA4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant172025
P30CA008748Cancer Center Support Grant112025
P30CA030199Cancer Center Support Grant (CCSG)102025
P30CA068485Cancer Center Support Grant62025
R01NS121103Novel mechanisms suppressing the pro-resolving phenotype of peripheral innate immunity following traumatic brain injury52025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)52025
ZIABC010441Biomolecular Recognition and Binding Mechanisms52025
P30CA016086Cancer Center Support Grant42025
P30CA016087Cancer Center Support Grant42025
R01DA022727Cell-Contact Mediated Mechanisms Assembling Synapses (R01DA022727)42025

1 to 10 of 1,711Source NIH's project files

See all 1,711 nih grants

Papers2,263

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Molecular epidemiology of enterotoxigenic Staphylococcus in marine fish from southeast India: public health implications.Int J Environ Health Res202642758471PubTator, text miningPubMed
Menin orchestrates corticogenesis via regulation of chromatin accessibility and activation of EphA4 in late-born neurons.Cell Rep202642671915PubTator, text miningPubMed
Identifying novel druggable targets and repurposable drugs for premature ovarian insufficiency by integrated multiomics and causal inference analysis.Geroscience202642663799PubTator, text miningPubMed
EphA4 Mediates Protumoral and Antitumoral Effects through Upstream Negative Regulation of AKT in Head and Neck Squamous Cell Carcinoma.Cancer Immunol Res202642644611PubTator, text miningPubMed
Circulating Ephrin-Eph Signaling Reflects Interstitial Fibrosis and Tubular Atrophy in Diabetic Kidney Disease.Clin J Am Soc Nephrol202642627699PubTator, text miningPubMed
Gem-Dimethyl Selenoketal: Suppressing Sulfur-Selenium Exchange with Antioxidant and Anti-Inflammatory Activities.J Am Chem Soc202642619073PubTator, text miningPubMed
Distinct competitive and allosteric binding modes of nanobodies targeting EphA4.J Biol Chem202642556722PubTator, text miningPubMed
Quantification of Binding of Small Molecules to Native Kinases by Flow Cytometry Reveals Divergence from Biochemical Affinities.J Am Chem Soc202642336767PubTator, text miningPubMed
Corrigendum to "Cross-species single-cell and spatial transcriptomic mapping reveals EFNA1-EPHA4-mediated stem-like epithelial-macrophage crosstalk driving colorectal cancer progression" [Cancer Letters 649 (2026) 218495].
Cancer Lett202642285780PubTator, text miningPubMed
Identification of targetable epitope surfaces from the high resolution structure of the superantigen Staphylococcal enterotoxin L.Sci Rep202642265145PubTator, text miningPubMed

1 to 10 of 2,263

See all 2,263 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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