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Gene · 2046

EPHA8: EPH receptor A8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EPHA8: EPH receptor A8. Genes, record 2046. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2046

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Gene

Symbol
EPHA8
HGNC
Name
EPH receptor A8
HGNC
NCBI Gene ID
2046
NCBI Gene
HGNC ID
HGNC:3391
HGNC
Ensembl
ENSG00000070886
NCBI Gene
Aliases
EEK, EK3, HEK3, Hek3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P29322Ephrin type-A receptor 81,0053Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445084P29322Espacenet
EP 4650780 A22025-11-19131P29322Espacenet
EP 4641201 A22025-10-29107P29322Espacenet
JP 2025147176 A2025-10-064821P29322Espacenet
JP 2025529142 A2025-09-041419P29322Espacenet
JP 2025529142 A2025-09-046275P29322Espacenet
US 12371689 B22025-07-291419P29322Espacenet
US 12371689 B22025-07-296275P29322Espacenet
JP 2025517969 A2025-06-12107P29322Espacenet
JP 2025517970 A2025-06-12131P29322Espacenet

1 to 10 of 49

See all 49 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
VANDETANIBCHEMBL24828Ephrin receptor inhibitorINHIBITOR

Source ChEMBL

Trials97

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06482086VANDETANIBPHASE2ClinicalTrials.gov
NCT04211337VANDETANIBPHASE32024-06-13ClinicalTrials.gov
NCT03630120VANDETANIBPHASE22021-01-22ClinicalTrials.gov
NCT03291379VANDETANIBEARLY_PHASE12021-02-03ClinicalTrials.gov
NCT02638428VANDETANIBPHASE2ClinicalTrials.gov
NCT02530411VANDETANIBPHASE2ClinicalTrials.gov
NCT02495103VANDETANIBPHASE1/PHASE22021-01-26ClinicalTrials.gov
NCT02299999VANDETANIBPHASE2ClinicalTrials.gov
NCT02117167VANDETANIBPHASE2ClinicalTrials.gov
NCT02109250VANDETANIBClinicalTrials.gov

1 to 10 of 97

See all 97 trials

NIH grants1,520

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEPHA8 papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
R35GM118062Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics92025
RM1HG009490Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease92025
P30CA016672Cancer Center Support Grant72025
P30CA023168Cancer Center Support Grant42025
P30CA036727Buffett Cancer Center Support Grant42025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant32025
T32CA009476Cancer Biology Training Program32025
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR22025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias22025

1 to 10 of 1,520Source NIH's project files

See all 1,520 nih grants

Papers2,828

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
JAK3 regulates PIP5K expression, promotes PIP2 generation and Ca2+ driven platelet activation in arterial thrombosis.Blood202642766692PubTator, text miningPubMed
SASH1 as a Context-Dependent Multi-Docking Scaffold Linking Receptor Signaling to Cytoskeletal Dynamics.Int J Mol Sci202642589701PubTator, text miningPubMed
Burden of rare genetic variants in genes associated with cancer among Malawian cervical cancer patients.Afr J Lab Med202642266196PubTator, text miningPubMed
Combining network pharmacology and experimental validation to study the action and mechanism of brusatol against lung adenocarcinoma.Sci Rep202641933050PubTator, text miningPubMed
Systems biology analysis uncovers a ROS-associated gene signature and immunomodulatory role of CLEC4E in ischemic stroke.PLoS One202641805714PubTator, text miningPubMed
lncRNAs: key player in Aβ deposition.RNA Biol202641784271PubTator, text miningPubMed
Identification of Novel Extracellular-Signal-Regulated Kinase 2 Inhibitors Through Machine Learning-Driven De Novo Design, Molecular Docking, and Free-Energy Perturbation.Pharmaceuticals (Basel)202641754877PubTator, text miningPubMed
Frags2Drugs: A Novel In Silico Fragment-Based Approach to the Discovery of Kinase Inhibitors.Pharmaceuticals (Basel)202641754848PubTator, text miningPubMed
Epigenetic Landscape of Female Infertility: An Integrated Bioinformatics Perspective on DNA Methylation, MicroRNAs, and Gene Regulatory Networks Across PCOS, Endometriosis, and Diminished Ovarian Reserve.
Int J Mol Sci202641751922PubTator, text miningPubMed
CRISPR-associated transposon for programmable viral vector engineering and prime editing.Nucleic Acids Res202641728946PubTator, text miningPubMed

1 to 10 of 2,828

See all 2,828 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2046

GET https://conductscience.org/api/genes/v1/2046/patents?page=2