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EPHB2: EPH receptor B2

1 protein, 82 patents, 1 drug, 97 trials, 9,146 NIH grants and 15,566 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEPHB2HGNC
NameEPH receptor B2HGNC
NCBI Gene ID2048NCBI Gene
HGNC IDHGNC:3393HGNC
EnsemblENSG00000133216NCBI Gene
AliasesBDPLT22, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29323Ephrin type-B receptor 21,0555Ensembl, GeneID, HGNCUniProt

Patents 82

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2025259600 A22025-12-1839P29323Espacenet
EP 4650780 A22025-11-1911706P29323Espacenet
EP 4641201 A22025-10-2912384P29323Espacenet
JP 2025147176 A2025-10-064824P29323Espacenet
JP 2025529142 A2025-09-041421P29323Espacenet
JP 2025529142 A2025-09-046276P29323Espacenet
US 12371689 B22025-07-291421P29323Espacenet
US 12371689 B22025-07-296276P29323Espacenet
JP 2025517969 A2025-06-1212384P29323Espacenet
JP 2025517970 A2025-06-1211706P29323Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
VANDETANIBCHEMBL24828Ephrin receptor inhibitorINHIBITORChEMBL

Trials 97

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06482086VANDETANIBPHASE2ClinicalTrials.gov
NCT04211337VANDETANIBPHASE32024-06-13ClinicalTrials.gov
NCT03630120VANDETANIBPHASE22021-01-22ClinicalTrials.gov
NCT03291379VANDETANIBEARLY_PHASE12021-02-03ClinicalTrials.gov
NCT02638428VANDETANIBPHASE2ClinicalTrials.gov
NCT02530411VANDETANIBPHASE2ClinicalTrials.gov
NCT02495103VANDETANIBPHASE1/PHASE22021-01-26ClinicalTrials.gov
NCT02299999VANDETANIBPHASE2ClinicalTrials.gov
NCT02117167VANDETANIBPHASE2ClinicalTrials.gov
NCT02109250VANDETANIBClinicalTrials.gov

NIH grants 9146

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1552,025NIH's project files
P30CA008748Cancer Center Support Grant1112,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant412,025NIH's project files
P30CA006973Regional Oncology Research Center352,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant352,025NIH's project files
P30CA068485Cancer Center Support Grant342,025NIH's project files
P30CA016058Cancer Center Support Grant302,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase282,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support222,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)222,025NIH's project files

Papers 15566

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824816PubTator, text miningPubMed
42822756PubTator, text miningPubMed
42818202PubTator, text miningPubMed
42810192PubTator, text miningPubMed
42803182PubTator, text miningPubMed
42793099PubTator, text miningPubMed
42779967PubTator, text miningPubMed
42772568PubTator, text miningPubMed
42769432PubTator, text miningPubMed
42762961PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license