ConductScience.org, home

Gene · 2050

EPHB4: EPH receptor B4

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. EPHB4: EPH receptor B4. Genes, record 2050. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2050

On this page

Gene

Symbol
EPHB4
HGNC
Name
EPH receptor B4
HGNC
NCBI Gene ID
2050
NCBI Gene
HGNC ID
HGNC:3395
HGNC
Ensembl
ENSG00000196411
NCBI Gene
Aliases
CMAVM2, HFASD, HTK, LMPHM7, MYK1, TYRO11, Tyro11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P54760Ephrin type-B receptor 498723Ensembl, GeneID, HGNC

Source UniProt

Patents137

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025259600 A22025-12-1843P54760Espacenet
EP 4650780 A22025-11-197515P54760Espacenet
EP 4641201 A22025-10-297509P54760Espacenet
JP 2025147176 A2025-10-064829P54760Espacenet
JP 2025529142 A2025-09-041423P54760Espacenet
JP 2025529142 A2025-09-046277P54760Espacenet
US 12371689 B22025-07-291423P54760Espacenet
US 12371689 B22025-07-296277P54760Espacenet
JP 2025517969 A2025-06-127509P54760Espacenet
JP 2025517970 A2025-06-127515P54760Espacenet

1 to 10 of 137

See all 137 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
JI-101CHEMBL3545155Ephrin type-B receptor 4 inhibitorINHIBITORChEMBL
TESEVATINIBCHEMBL3544983Ephrin type-B receptor 4 inhibitorINHIBITORChEMBL
TG100-801CHEMBL403989Ephrin type-B receptor 4 inhibitorINHIBITORChEMBL
VANDETANIBCHEMBL24828Ephrin receptor inhibitorINHIBITORChEMBL

Trials109

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06482086VANDETANIBPHASE2ClinicalTrials.gov
NCT04211337VANDETANIBPHASE32024-06-13ClinicalTrials.gov
NCT03630120VANDETANIBPHASE22021-01-22ClinicalTrials.gov
NCT03291379VANDETANIBEARLY_PHASE12021-02-03ClinicalTrials.gov
NCT03203642TESEVATINIBPHASE22023-02-06ClinicalTrials.gov
NCT03096080TESEVATINIBPHASE1ClinicalTrials.gov
NCT02844439TESEVATINIBPHASE22021-09-22ClinicalTrials.gov
NCT02638428VANDETANIBPHASE2ClinicalTrials.gov
NCT02616393TESEVATINIBPHASE22021-11-23ClinicalTrials.gov
NCT02616055TESEVATINIBPHASE2ClinicalTrials.gov

1 to 10 of 109

See all 109 trials

NIH grants1,441

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEPHB4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant182025
P30CA046934University of Colorado Cancer Center Support Grant122025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)72025
R01DE028529Tackling Treg mediated resistance to radiation and anti-PDL1 in HNSCC's72025
P30CA006973Regional Oncology Research Center62025
P30CA008748Cancer Center Support Grant62025
P30CA068485Cancer Center Support Grant62025
P30CA076292Moffitt Cancer Center Support Grant62025
T32GM086287Research Training in Anesthesia62025
UL1TR001863Yale Clinical and Translational Science Award62025

1 to 10 of 1,441Source NIH's project files

See all 1,441 nih grants

Papers2,238

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical and molecular characterization of non-PIK3CA-related vascular malformations with overgrowth in a pediatric cohort.World J Pediatr202642814223PubTator, text miningPubMed
Discovery of Sennoside A as a Natural O-GlcNAcase Inhibitor That Ameliorates Parkinson's Disease by Restoring EphrinB2 O-GlcNAcylation.Research (Wash D C)202642718897PubTator, text miningPubMed
Macrophages Drive Ferroptosis Resistance after Radiotherapy.Cancer Commun (Lond)202642698964PubTator, text miningPubMed
Proteome-wide genetic study identified therapeutic targets for early-onset and late-onset Alzheimer's disease.Int J Surg202642682321PubTator, text miningPubMed
Retraction notice to "Biological function of EPHB4 in the aging process of vascular endothelial cells: mtDNA molecular mechanism and MAPK/PGC-1/TFAM signaling pathway" [Int. J. Biol. Macromol. 293 (2025) 138536].
Int J Biol Macromol202642527189PubTator, text miningPubMed
Identification and analysis of EphrinB2/EphB4 signaling pathway and angiogenesis related biomarkers in coronary artery disease based on bioinformatics.J Cardiothorac Surg202642477815PubTator, text miningPubMed
Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling.J Periodontal Res202642403364PubTator, text miningPubMed
EphB4 inhibition defines a druggable synthetic-lethal vulnerability in MYC-driven triple-negative breast cancer.Cell Death Dis202642362505PubTator, text miningPubMed
Capillary Malformation-Arteriovenous Malformation Syndrome Associated with RASA1 and EPHB4 Mutations: Comparative Case Series and Narrative Review.Life (Basel)202642355527PubTator, text miningPubMed
Homoharringtonine Impedes Migration and Invasion by Inhibiting EphB4/SRI/EMT Signaling and Enhances the Antimetastatic Abilities of Erlotinib in Pancreatic Cancer.Curr Cancer Drug Targets202642333561PubTator, text miningPubMed

1 to 10 of 2,238

See all 2,238 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2050

GET https://conductscience.org/api/genes/v1/2050/patents?page=2