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Gene · 2052

EPHX1: epoxide hydrolase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EPHX1: epoxide hydrolase 1. Genes, record 2052. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2052

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Gene

Symbol
EPHX1
HGNC
Name
epoxide hydrolase 1
HGNC
NCBI Gene ID
2052
NCBI Gene
HGNC ID
HGNC:3401
HGNC
Ensembl
ENSG00000143819
NCBI Gene
Aliases
EPHX, EPOX, HYL1, MEH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07099Epoxide hydrolase 14550Ensembl, GeneID, HGNC

Source UniProt

Patents151

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445137P07099Espacenet
JP 2026004568 A2026-01-1445138P07099Espacenet
EP 4650780 A22025-11-192801P07099Espacenet
EP 4641201 A22025-10-292367P07099Espacenet
JP 2025517969 A2025-06-122367P07099Espacenet
JP 2025517970 A2025-06-122801P07099Espacenet
US 11694765 B22023-07-04352P07099Espacenet
JP 2023049296 A2023-04-1031P07099Espacenet
US 11446398 B22022-09-2027810P07099Espacenet
US 11446398 B22022-09-2027811P07099Espacenet

1 to 10 of 151

See all 151 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,407

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEPHX1 papersNewest fiscal year
R35ES030443Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases152025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment112025
P30ES010126UNC Center for Environmental Health and Susceptibility112025
P30ES007048Environmental Exposures, Host Factors and Human Disease102025
ZIAES025034Characterization And Functional Significance Of P450 Arachidonate Epoxygenases82025
T32HL007427SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES72025
P30ES005605Environmental Health Sciences Research Center62025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures52025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)42025
P30CA016672Cancer Center Support Grant42025

1 to 10 of 1,407Source NIH's project files

See all 1,407 nih grants

Papers2,230

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative multi-omics analyses suggest a candidate microbial metabolite-associated host gene network in ulcerative colitis.Immunol Res202642696087PubTator, text miningPubMed
Transcriptomic Analysis Reveals Core Genes and Mechanisms Linking Grilled Food Toxicants (4-HNE, BaP, PhIP) to NASH-HCC Progression.Food Sci Nutr202642682783PubTator, text miningPubMed
Environmental risk and genetic susceptibility in Alzheimer's disease: Impacts on cognitive function and biomarkers.J Alzheimers Dis202642179068PubTator, text miningPubMed
Epoxide Hydrolase Family: Biological Functions, Disease Mechanisms, and Emerging Therapeutic Strategies.Biology (Basel)202642117830PubTator, text miningPubMed
Genetic basis of phytoalexin-mediated chemical defense in plants.Cell202642105761PubTator, text miningPubMed
Clinically confirmed cohort reveals antioxidant genetic polymorphisms as potential susceptibility factors for long COVID after mild or asymptomatic COVID-19.Free Radic Biol Med202641903617PubTator, text miningPubMed
Integrated Bioinformatics Analysis Reveals the Impact of SHEV ORF3-Related LncRNA Network on Bile Secretion Pathway (ko 04976) in HepG2 Cells.Vet Sci202641893693PubTator, text miningPubMed
Limonin induces ferroptosis in cervical squamous cell carcinoma by activating the expression of soluble epoxide hydrolase 2 protein.PLoS One202641838669PubTator, text miningPubMed
Advancing the bioassay ontology through integrated PK/PD and safety pharmacology representation.J Biomed Semantics202641821121PubTator, text miningPubMed
Phosphorylations of serines 21/9 in glycogen synthase kinase 3α/β are dispensable for V600EBRAF-driven premalignant tumour development in the mouse intestine.PLoS One202641790744PubTator, text miningPubMed

1 to 10 of 2,230

See all 2,230 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2052

GET https://conductscience.org/api/genes/v1/2052/patents?page=2