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Gene · 2058

EPRS1: glutamyl-prolyl-tRNA synthetase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EPRS1: glutamyl-prolyl-tRNA synthetase 1. Genes, record 2058. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2058

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Gene

Symbol
EPRS1
HGNC
Name
glutamyl-prolyl-tRNA synthetase 1
HGNC
NCBI Gene ID
2058
NCBI Gene
HGNC ID
HGNC:3418
HGNC
Ensembl
ENSG00000136628
NCBI Gene
Aliases
EARS, EPRS, GLUPRORS, HLD15, PARS, PIG32, QARS, QPRS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07814Bifunctional glutamate/proline--tRNA ligase1,51233Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447853P07814Espacenet
EP 4650780 A22025-11-198129P07814Espacenet
EP 4641201 A22025-10-298285P07814Espacenet
JP 2025517969 A2025-06-128285P07814Espacenet
JP 2025517970 A2025-06-128129P07814Espacenet
US 11446398 B22022-09-2035241P07814Espacenet
JP 2022524081 A2022-04-27138212P07814Espacenet
US 11173192 B22021-11-1663P07814Espacenet
US 11078247 B22021-08-033616P07814Espacenet
WO 2020043864 A12020-03-052521P07814Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants805

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEPRS1 papersNewest fiscal year
R01NS124547The mammalian multi-tRNA synthetase complex52025
R01AI109023Defining P. falciparum resistance to artemisinin-based combination therapies42025
R01NS124581Childhood-onset hypomyelinating leukodystrophy and the multi-tRNA synthetase complex42025
ZIADK036165Study of the mechanism of bacterial chromosome partitioning systems42025
ZIAHD008814Mammalian iron-sulfur cluster biogenesis42025
P30CA016086Cancer Center Support Grant32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
R01AI040127Signal transduction and gene induction in lymphocytes32025
R01AI124678Elucidating the molecular basis of piperaquine resistance in Plasmodium falciparum32025
R01GM141242How bacterial SMC complexes organize chromosomes32025

1 to 10 of 805Source NIH's project files

See all 805 nih grants

Papers1,512

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Atomic-Level Structures Reveal How a Repurposed 3‑Aminopyrazine-2-carboxamide Scaffold Inhibits Mycobacterium tuberculosis Prolyl-tRNA Synthetase.ACS Omega202642825133PubTator, text miningPubMed
Identification of Secreted Modular Calcium-Binding Protein 1 as a Novel Endogenous Protective Molecule Against Acute Myocardial Infarction-Induced Cardiac Rupture.Circulation202642808155PubTator, text miningPubMed
A sesterterpenoid derivative alleviates ulcerative colitis through targeting ProRS to suppress the NLRP3 inflammasome.Sci China Life Sci202642752779PubTator, text miningPubMed
Fast assembly and in vivo coalescence of ParBF biocondensates involved in bacterial DNA partition.Nucleic Acids Res202642573070PubTator, text miningPubMed
The Effect of Food on the Pharmacokinetics and Gastrointestinal Tolerability of Bersiporocin, a Novel Oral Prolyl-tRNA-Synthetase Inhibitor.Drug Des Devel Ther202642483482PubTator, text miningPubMed
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems.Nucleic Acids Res202642258539PubTator, text miningPubMed
Halofuginone suppresses HSV-2 through direct viral inhibition and host ProRS inhibition.Biochem Pharmacol202642140445PubTator, text miningPubMed
Label-free whole slide virtual multi-staining using dual-excitation photon absorption remote sensing microscopy.Npj Imaging202641917209PubTator, text miningPubMed
Poly(ADP-ribose) (PAR) exhibits ion-dependent structural properties distinct from RNA.Nucleic Acids Res202641891879PubTator, text miningPubMed
Connectivity of the Superior Temporal Polysensory Area With the Presubiculum, Parasubiculum, Entorhinal Cortex, and Claustrum-Endopiriform Complex in the Common Marmoset (Callithrix jacchus).J Comp Neurol202641878825PubTator, text miningPubMed

1 to 10 of 1,512

See all 1,512 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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