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ERBB2: erb-b2 receptor tyrosine kinase 2

1 protein, 781 patents, 50 drugs, 2,589 trials, 24,100 NIH grants and 150,300 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolERBB2HGNC
Nameerb-b2 receptor tyrosine kinase 2HGNC
NCBI Gene ID2064NCBI Gene
HGNC IDHGNC:3430HGNC
EnsemblENSG00000141736NCBI Gene
AliasesCD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2)NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04626Receptor tyrosine-protein kinase erbB-21,25563Ensembl, GeneID, HGNCUniProt

Patents 781

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026220001 A12026-10-22100P04626Espacenet
WO 2026215173 A12026-10-1574P04626Espacenet
WO 2026193167 A12026-09-171P04626Espacenet
WO 2026167227 A12026-08-134P04626Espacenet
EP 4782064 A22026-07-292P04626Espacenet
JP 2026120541 A2026-07-2237P04626Espacenet
JP 2026117046 A2026-07-1416P04626Espacenet
WO 2026121966 A22026-06-113P04626Espacenet
US 12649001 B22026-06-0941P04626Espacenet
JP 2026086770 A2026-05-2616P04626Espacenet

Drugs 50

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AC-480CHEMBL1645462Receptor protein-tyrosine kinase erbB-2 inhibitorINHIBITORChEMBL
AEE-788CHEMBL587723Receptor protein-tyrosine kinase erbB-2 inhibitorINHIBITORChEMBL
AFATINIBCHEMBL1173655Receptor protein-tyrosine kinase erbB-2 inhibitorINHIBITORChEMBL
AFATINIB DIMALEATECHEMBL2105712Receptor protein-tyrosine kinase erbB-2 inhibitorINHIBITORChEMBL
ALLITINIBCHEMBL1947204Receptor protein-tyrosine kinase erbB-2 inhibitorINHIBITORChEMBL
ANVATABART OPADOTINCHEMBL4297892Receptor protein-tyrosine kinase erbB-2 binding agentBINDING AGENTChEMBL
AV-412CHEMBL6067986Receptor protein-tyrosine kinase erbB-2 inhibitorINHIBITORChEMBL
AV-412 FREE BASECHEMBL2138625Receptor protein-tyrosine kinase erbB-2 inhibitorINHIBITORChEMBL
BMS-690514CHEMBL3545396Receptor protein-tyrosine kinase erbB-2 inhibitorINHIBITORChEMBL
CANERTINIBCHEMBL31965Receptor protein-tyrosine kinase erbB-2 inhibitorINHIBITORChEMBL

Trials 2589

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07597993TRASTUZUMAB DERUXTECANClinicalTrials.gov
NCT07597629KN-026PHASE2ClinicalTrials.gov
NCT07589972TRASTUZUMABClinicalTrials.gov
NCT07589972PERTUZUMABClinicalTrials.gov
NCT07584733DISITAMAB VEDOTINPHASE2ClinicalTrials.gov
NCT07582887TRASTUZUMAB DERUXTECANClinicalTrials.gov
NCT07581795TRASTUZUMABPHASE2ClinicalTrials.gov
NCT07581795PERTUZUMABPHASE2ClinicalTrials.gov
NCT07581574TRASTUZUMABPHASE1ClinicalTrials.gov
NCT07578116TRASTUZUMABPHASE3ClinicalTrials.gov

NIH grants 24100

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1,7172,025NIH's project files
P30CA016672Cancer Center Support Grant1,5912,025NIH's project files
P50CA058223SPORE in Breast Cancer3382,025NIH's project files
P30CA006973Regional Oncology Research Center2842,025NIH's project files
P30CA068485Cancer Center Support Grant2572,025NIH's project files
P30CA016086Cancer Center Support Grant2312,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant2302,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE2182,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant2022,025NIH's project files
P30CA016058Cancer Center Support Grant1962,025NIH's project files

Papers 150300

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827257PubTator, text miningPubMed
42826678PubTator, text miningPubMed
42826440PubTator, text miningPubMed
42825982PubTator, text miningPubMed
42825938PubTator, text miningPubMed
42825881PubTator, text miningPubMed
42825812PubTator, text miningPubMed
42824934PubTator, text miningPubMed
42824931PubTator, text miningPubMed
42824666PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license