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ERBB3: erb-b2 receptor tyrosine kinase 3

1 protein, 279 patents, 18 drugs, 190 trials, 5,986 NIH grants and 14,691 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolERBB3HGNC
Nameerb-b2 receptor tyrosine kinase 3HGNC
NCBI Gene ID2065NCBI Gene
HGNC IDHGNC:3431HGNC
EnsemblENSG00000065361NCBI Gene
AliasesErbB-3, FERLK, HER3, LCCS2, MDA-BF-1, VSCN1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P21860Receptor tyrosine-protein kinase erbB-31,34223Ensembl, GeneID, HGNCUniProt

Patents 279

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026215526 A12026-10-15102P21860Espacenet
WO 2026210006 A12026-10-0873P21860Espacenet
JP 2026120541 A2026-07-2239P21860Espacenet
JP 2026082857 A2026-05-1939P21860Espacenet
JP 2026513904 A2026-05-011P21860Espacenet
JP 2026514110 A2026-05-011P21860Espacenet
US 12600781 B22026-04-14471P21860Espacenet
EP 4684803 A12026-01-285P21860Espacenet
EP 4681734 A22026-01-2152P21860Espacenet
JP 2026500728 A2026-01-081P21860Espacenet

Drugs 18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMG-888CHEMBL2109396Receptor tyrosine-protein kinase erbB-3 inhibitorINHIBITORChEMBL
AV-203CHEMBL2109401Receptor tyrosine-protein kinase erbB-3 inhibitorINHIBITORChEMBL
CDX-3379CHEMBL4650292Receptor tyrosine-protein kinase erbB-3 inhibitorINHIBITORChEMBL
DULIGOTUZUMABCHEMBL3137345Receptor tyrosine-protein kinase erbB-3 inhibitorINHIBITORChEMBL
ELGEMTUMABCHEMBL4298013Receptor tyrosine-protein kinase erbB-3 inhibitorINHIBITORChEMBL
ISTIRATUMABCHEMBL3989990Receptor tyrosine-protein kinase erbB-3 inhibitorINHIBITORChEMBL
KBP5209CHEMBL4650289Epidermal growth factor receptor inhibitorINHIBITORChEMBL
LUMRETUZUMABCHEMBL3707404Receptor tyrosine-protein kinase erbB-3 inhibitorINHIBITORChEMBL
MM-111CHEMBL4297556ErbB-2/ErbB-3 heterodimer inhibitorINHIBITORChEMBL
PATRITUMABCHEMBL2109406Receptor tyrosine-protein kinase erbB-3 inhibitorINHIBITORChEMBL

Trials 190

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07060807PATRITUMAB DERUXTECANPHASE3ClinicalTrials.gov
NCT06941272PATRITUMAB DERUXTECANPHASE1/PHASE2ClinicalTrials.gov
NCT06797635PATRITUMAB DERUXTECANPHASE2ClinicalTrials.gov
NCT06780098PATRITUMAB DERUXTECANPHASE2ClinicalTrials.gov
NCT06731907PATRITUMAB DERUXTECANPHASE2ClinicalTrials.gov
NCT06686394PATRITUMAB DERUXTECANPHASE1/PHASE2ClinicalTrials.gov
NCT06482086VANDETANIBPHASE2ClinicalTrials.gov
NCT06469944PATRITUMAB DERUXTECANPHASE1/PHASE2ClinicalTrials.gov
NCT06445972PATRITUMAB DERUXTECANPHASE1/PHASE2ClinicalTrials.gov
NCT06298084PATRITUMAB DERUXTECANPHASE1/PHASE2ClinicalTrials.gov

NIH grants 5986

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2022,025NIH's project files
P30CA016672Cancer Center Support Grant1992,025NIH's project files
P30CA068485Cancer Center Support Grant612,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant352,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support332,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase302,025NIH's project files
P30CA016058Cancer Center Support Grant292,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant292,025NIH's project files
P30CA006973Regional Oncology Research Center282,025NIH's project files
P30CA093373Cancer Center Support Grant P30282,025NIH's project files

Papers 14691

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820299PubTator, text miningPubMed
42818202PubTator, text miningPubMed
42817222PubTator, text miningPubMed
42815252PubTator, text miningPubMed
42813642PubTator, text miningPubMed
42809553PubTator, text miningPubMed
42808379PubTator, text miningPubMed
42806904PubTator, text miningPubMed
42793224PubTator, text miningPubMed
42785914PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license