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ERBB4: erb-b2 receptor tyrosine kinase 4

1 protein, 127 patents, 15 drugs, 412 trials, 5,364 NIH grants and 11,041 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolERBB4HGNC
Nameerb-b2 receptor tyrosine kinase 4HGNC
NCBI Gene ID2066NCBI Gene
HGNC IDHGNC:3432HGNC
EnsemblENSG00000178568NCBI Gene
AliasesALS19, HER4, p180erbB4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q15303Receptor tyrosine-protein kinase erbB-41,30814Ensembl, GeneID, HGNCUniProt

Patents 127

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4681734 A22026-01-2153Q15303Espacenet
EP 4650780 A22025-11-196725Q15303Espacenet
EP 4641201 A22025-10-296492Q15303Espacenet
JP 2025529142 A2025-09-041430Q15303Espacenet
US 12371689 B22025-07-291430Q15303Espacenet
JP 2025517969 A2025-06-126492Q15303Espacenet
JP 2025517970 A2025-06-126725Q15303Espacenet
JP 2025032204 A2025-03-1127913Q15303Espacenet
WO 2025049818 A12025-03-0646Q15303Espacenet
EP 4487869 A22025-01-08158Q15303Espacenet

Drugs 15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AC-480CHEMBL1645462Receptor protein-tyrosine kinase erbB-4 inhibitorINHIBITORChEMBL
AFATINIBCHEMBL1173655Receptor protein-tyrosine kinase erbB-4 inhibitorINHIBITORChEMBL
AFATINIB DIMALEATECHEMBL2105712Receptor protein-tyrosine kinase erbB-4 inhibitorINHIBITORChEMBL
BMS-690514CHEMBL3545396Receptor protein-tyrosine kinase erbB-4 inhibitorINHIBITORChEMBL
CANERTINIBCHEMBL31965Receptor protein-tyrosine kinase erbB-4 inhibitorINHIBITORChEMBL
CANERTINIB DIHYDROCHLORIDECHEMBL545315Receptor protein-tyrosine kinase erbB-4 inhibitorINHIBITORChEMBL
DACOMITINIBCHEMBL2105719Receptor protein-tyrosine kinase erbB-4 inhibitorINHIBITORChEMBL
DACOMITINIB ANHYDROUSCHEMBL2110732Receptor protein-tyrosine kinase erbB-4 inhibitorINHIBITORChEMBL
JNJ-26483327CHEMBL3109738Receptor protein-tyrosine kinase erbB-4 inhibitorINHIBITORChEMBL
KBP5209CHEMBL4650289Epidermal growth factor receptor inhibitorINHIBITORChEMBL

Trials 412

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07333937NERATINIBPHASE2ClinicalTrials.gov
NCT07271446AFATINIBPHASE1ClinicalTrials.gov
NCT07185997AFATINIBPHASE3ClinicalTrials.gov
NCT07152782NERATINIBPHASE2ClinicalTrials.gov
NCT07040956AFATINIBPHASE2ClinicalTrials.gov
NCT07019272NERATINIBClinicalTrials.gov
NCT07010120AFATINIBPHASE1/PHASE2ClinicalTrials.gov
NCT06813079NERATINIBPHASE2ClinicalTrials.gov
NCT06804850AFATINIBPHASE2ClinicalTrials.gov
NCT06759857AFATINIBPHASE3ClinicalTrials.gov

NIH grants 5364

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1252,025NIH's project files
P30CA008748Cancer Center Support Grant872,025NIH's project files
P30CA068485Cancer Center Support Grant442,025NIH's project files
P30CA016058Cancer Center Support Grant292,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase242,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award172,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support162,025NIH's project files
P50CA058223SPORE in Breast Cancer162,025NIH's project files
P30CA016359Cancer Center Support Grant152,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant152,025NIH's project files

Papers 11041

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824453PubTator, text miningPubMed
42786848PubTator, text miningPubMed
42785914PubTator, text miningPubMed
42782811PubTator, text miningPubMed
42782805PubTator, text miningPubMed
42776076PubTator, text miningPubMed
42763821PubTator, text miningPubMed
42762093PubTator, text miningPubMed
42759101PubTator, text miningPubMed
42737734PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license