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ERCC1: ERCC excision repair 1, endonuclease non-catalytic subunit

1 protein, 57 patents, 0 drugs, 0 trials, 2,860 NIH grants and 6,653 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolERCC1HGNC
NameERCC excision repair 1, endonuclease non-catalytic subunitHGNC
NCBI Gene ID2067NCBI Gene
HGNC IDHGNC:3433HGNC
EnsemblENSG00000012061NCBI Gene
AliasesCOFS4, RAD10, UV20NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P07992DNA excision repair protein ERCC-129714Ensembl, GeneID, HGNCUniProt

Patents 57

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194027P07992Espacenet
WO 2025217591 A12025-10-1654P07992Espacenet
JP 2025147176 A2025-10-0616589P07992Espacenet
JP 2025517970 A2025-06-124027P07992Espacenet
JP 2025028160 A2025-02-2816589P07992Espacenet
KR 1020250010750 A2025-01-2116589P07992Espacenet
EP 4464338 A22024-11-20308P07992Espacenet
JP 2024123008 A2024-09-106115P07992Espacenet
JP 2024109657 A2024-08-1416428P07992Espacenet
US 11680268 B22023-06-20308P07992Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2860

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant632,025NIH's project files
P01CA092584Structural Cell Biology of DNA Repair Machines432,025NIH's project files
P30CA008748Cancer Center Support Grant242,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility202,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)182,025NIH's project files
P30CA047904Cancer Center Support Grant172,025NIH's project files
R01CA093729Repair of Genome Destabilizing DNA Structures162,025NIH's project files
U19AG056278Genetic variant-based drug discovery targeting conserved pathways of aging152,025NIH's project files
P01AG062413Targeting Cellular Senescence to Extend Healthspan142,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT142,025NIH's project files

Papers 6653

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42778593PubTator, text miningPubMed
42777141PubTator, text miningPubMed
42770890PubTator, text miningPubMed
42745665PubTator, text miningPubMed
42725560PubTator, text miningPubMed
42712445PubTator, text miningPubMed
42683001PubTator, text miningPubMed
42603641PubTator, text miningPubMed
42558488PubTator, text miningPubMed
42484294PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license