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ERCC2: ERCC excision repair 2, TFIIH core complex helicase subunit

1 protein, 47 patents, 0 drugs, 0 trials, 2,509 NIH grants and 5,113 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolERCC2HGNC
NameERCC excision repair 2, TFIIH core complex helicase subunitHGNC
NCBI Gene ID2068NCBI Gene
HGNC IDHGNC:3434HGNC
EnsemblENSG00000104884NCBI Gene
AliasesCOFS2, CXPD, EM9, MAG, MGC102762, MGC126218, MGC126219, TFIIH, TTD, TTD1, XPDNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P18074General transcription and DNA repair factor IIH helicase subunit XPD76051Ensembl, GeneID, HGNCUniProt

Patents 47

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1910875P18074Espacenet
EP 4640849 A22025-10-291655P18074Espacenet
EP 4641201 A22025-10-2911238P18074Espacenet
JP 2025519096 A2025-06-241655P18074Espacenet
JP 2025517969 A2025-06-1211238P18074Espacenet
JP 2025517970 A2025-06-1210875P18074Espacenet
EP 4524569 A22025-03-1922P18074Espacenet
EP 4464338 A22024-11-20380P18074Espacenet
JP 2024123008 A2024-09-106124P18074Espacenet
US 12023339 B22024-07-0222P18074Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2509

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant552,025NIH's project files
P01CA092584Structural Cell Biology of DNA Repair Machines472,025NIH's project files
P30CA016672Cancer Center Support Grant392,025NIH's project files
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability272,025NIH's project files
ZIAAG000753Fanconi Anemia Pathway262,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility252,025NIH's project files
ZIAAG000752Model Genetic Systems to Study DNA Repair172,025NIH's project files
P30ES009089Center for Environmental Health in Northern Manhattan152,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase102,025NIH's project files
P30CA014599Cancer Center Support Grant102,025NIH's project files

Papers 5113

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42804718PubTator, text miningPubMed
42771879PubTator, text miningPubMed
42735122PubTator, text miningPubMed
42653251PubTator, text miningPubMed
42627456PubTator, text miningPubMed
42480520PubTator, text miningPubMed
42464029PubTator, text miningPubMed
42377264PubTator, text miningPubMed
42375929PubTator, text miningPubMed
42367015PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license