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EREG: epiregulin

1 protein, 98 patents, 1 drug, 5 trials, 20,542 NIH grants and 70,888 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEREGHGNC
NameepiregulinHGNC
NCBI Gene ID2069NCBI Gene
HGNC IDHGNC:3443HGNC
EnsemblENSG00000124882NCBI Gene
AliasesEPR, ER, EpNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O14944Proepiregulin1698Ensembl, GeneID, HGNCUniProt

Patents 98

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191141O14944Espacenet
JP 2025138725 A2025-09-251877O14944Espacenet
US 12419201 B22025-09-231O14944Espacenet
JP 2025529142 A2025-09-041431O14944Espacenet
US 12371689 B22025-07-291431O14944Espacenet
JP 2025102800 A2025-07-083O14944Espacenet
JP 2025517970 A2025-06-121141O14944Espacenet
EP 4484957 A12025-01-013O14944Espacenet
US 11858987 B22024-01-023O14944Espacenet
JP 2023159269 A2023-10-313O14944Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
FEPIXNEBARTCHEMBL4594573Proepiregulin inhibitorINHIBITORChEMBL

Trials 5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05986292FEPIXNEBARTPHASE2ClinicalTrials.gov
NCT04529096FEPIXNEBARTPHASE22022-06-23ClinicalTrials.gov
NCT04476108FEPIXNEBARTPHASE22022-08-03ClinicalTrials.gov
NCT04456686FEPIXNEBARTPHASE22022-06-23ClinicalTrials.gov
NCT01774981FEPIXNEBARTPHASE1/PHASE22017-08-15ClinicalTrials.gov

NIH grants 20542

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant5972,025NIH's project files
P30CA016672Cancer Center Support Grant5052,025NIH's project files
P50CA058223SPORE in Breast Cancer1672,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE1602,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant1432,025NIH's project files
P30CA068485Cancer Center Support Grant1372,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant1272,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant1252,025NIH's project files
P30CA016086Cancer Center Support Grant1102,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility1052,025NIH's project files

Papers 70888

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825327PubTator, text miningPubMed
42823971PubTator, text miningPubMed
42823086PubTator, text miningPubMed
42822240PubTator, text miningPubMed
42821234PubTator, text miningPubMed
42820956PubTator, text miningPubMed
42819089PubTator, text miningPubMed
42818478PubTator, text miningPubMed
42818363PubTator, text miningPubMed
42818202PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license