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AKT1: AKT serine/threonine kinase 1

1 protein, 274 patents, 16 drugs, 175 trials, 49,468 NIH grants and 262,177 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAKT1HGNC
NameAKT serine/threonine kinase 1HGNC
NCBI Gene ID207NCBI Gene
HGNC IDHGNC:391HGNC
EnsemblENSG00000142208NCBI Gene
AliasesAKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, RAC-alphaNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P31749RAC-alpha serine/threonine-protein kinase48044Ensembl, GeneID, HGNCUniProt

Patents 274

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12544448 B22026-02-105P31749Espacenet
US 12539305 B22026-02-035P31749Espacenet
JP 2026004568 A2026-01-1469515P31749Espacenet
JP 2026004568 A2026-01-1469516P31749Espacenet
JP 2026004568 A2026-01-1469518P31749Espacenet
JP 2026004568 A2026-01-1469519P31749Espacenet
JP 2026004568 A2026-01-1469520P31749Espacenet
EP 4650780 A22025-11-192732P31749Espacenet
JP 2025157475 A2025-10-1556P31749Espacenet
JP 2025147176 A2025-10-0614718P31749Espacenet

Drugs 16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFURESERTIBCHEMBL2219422Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
BAY-1125976CHEMBL4751394Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
CAPIVASERTIBCHEMBL2325741Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
GSK-690693CHEMBL494089Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
IPATASERTIBCHEMBL2177390Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
LY-2780301CHEMBL3545134Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
MIRANSERTIBCHEMBL4297188Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
MK-2201CHEMBL3545000Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
MK-2206CHEMBL1079175Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
PIFUSERTIBCHEMBL4297329Serine/threonine-protein kinase AKT negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL

Trials 175

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07486648CAPIVASERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT07426822CAPIVASERTIBPHASE2ClinicalTrials.gov
NCT07294677CAPIVASERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT07281833CAPIVASERTIBPHASE3ClinicalTrials.gov
NCT07175415CAPIVASERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT06837792CAPIVASERTIBPHASE2ClinicalTrials.gov
NCT06764186CAPIVASERTIBPHASE3ClinicalTrials.gov
NCT06635447CAPIVASERTIBPHASE3ClinicalTrials.gov
NCT06613516CAPIVASERTIBPHASE2ClinicalTrials.gov
NCT06607757CAPIVASERTIBPHASE2ClinicalTrials.gov

NIH grants 49468

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1,8102,025NIH's project files
P30CA008748Cancer Center Support Grant1,1602,025NIH's project files
P30CA016058Cancer Center Support Grant2922,025NIH's project files
P30CA006973Regional Oncology Research Center2752,025NIH's project files
P30CA068485Cancer Center Support Grant2552,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant2462,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant2252,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase2242,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award2182,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant1972,025NIH's project files

Papers 262177

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827403PubTator, text miningPubMed
42827142PubTator, text miningPubMed
42826912PubTator, text miningPubMed
42826880PubTator, text miningPubMed
42826809PubTator, text miningPubMed
42826660PubTator, text miningPubMed
42826084PubTator, text miningPubMed
42825943PubTator, text miningPubMed
42825856PubTator, text miningPubMed
42825378PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license