Gene · 2071
ERCC3: ERCC excision repair 3, TFIIH core complex helicase subunit
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ERCC3: ERCC excision repair 3, TFIIH core complex helicase subunit. Genes, record 2071. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2071
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P19447 | General transcription and DNA repair factor IIH helicase/translocase subunit XPB | 782 | 52 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 45603 | P19447 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 376 | P19447 | Espacenet |
| US 11976334 B2 | 2024-05-07 | 141 | P19447 | Espacenet |
| US 11834686 B2 | 2023-12-05 | 59 | P19447 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 376 | P19447 | Espacenet |
| US 11597924 B2 | 2023-03-07 | 50 | P19447 | Espacenet |
| US 11504404 B2 | 2022-11-22 | 179 | P19447 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 29009 | P19447 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 131980 | P19447 | Espacenet |
| JP 2021536229 A | 2021-12-27 | 72 | P19447 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,695
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ERCC3 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 30 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 20 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 20 | 2025 |
| ZIAAG000741 | Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability | 13 | 2025 |
| ZIAAG000753 | Fanconi Anemia Pathway | 13 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 11 | 2025 |
| ZIASC009144 | Mechanisms of transcription factor integration at the c-myc promoter | 10 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 8 | 2025 |
| ZIAAG000752 | Model Genetic Systems to Study DNA Repair | 8 | 2025 |
| R01ES025987 | Environmental DNA Lesions and Mutagenesis: Molecular Mechanisms of Lesion Recognition for Repair and Polymerase Bypass | 7 | 2025 |
1 to 10 of 1,695Source NIH's project files
See all 1,695 nih grantsPapers2,382
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| XPA confers ability of endonucleases to act processively and to incise damaged nucleosomal DNA. | Exp Biol Med (Maywood) | 2026 | 42643815 | PubTator, text mining | PubMed |
| TIP60 promotes chemoresistance by limiting intracellular platinum accumulation and enhancing removal of cisplatin-DNA adducts. | J Biol Chem | 2026 | 42463050 | PubTator, text mining | PubMed |
| Genetic Determinants of T-Cell Homeostasis in Critical Illness: An Exploratory Analysis of Immune Gene Variants and TREC Dynamics. | J Pers Med | 2026 | 42346589 | PubTator, text mining | PubMed |
| Correction to "Imaging-Based High-Content Screening With Clickable Probes Identifies XPB Inhibitors". | Angew Chem Int Ed Engl | 2026 | 42338054 | PubTator, text mining | PubMed |
| RNA polymerase II transcription initiation with and without XPB translocase activity. | Commun Biol | 2026 | 42098258 | PubTator, text mining | PubMed |
| Integrated DNA Repair Capacity and NER Gene Expression for Improving Risk Prediction in Head and Neck Squamous Cell Carcinoma. | Curr Med Sci | 2026 | 42081182 | PubTator, text mining | PubMed |
| Triptolide: A Narrative Review of Its Traditional Use, Derivatives, Pharmacology, Antitumor Effect, and Clinical Applications. | Cancers (Basel) | 2026 | 42073523 | PubTator, text mining | PubMed |
| Genome Sequencing of Undiagnosed European Patients Suspected of Hereditary Cancer: Diagnostic Yield and Identification of Candidate Causative Variants. | JCO Precis Oncol | 2026 | 41990296 | PubTator, text mining | PubMed |
| Chemotherapy with bevacizumab and pembrolizumab followed by radiotherapy for unclassified round cell sarcomas of the gallbladder: A case report and review of literature. | Transl Oncol | 2026 | 41956009 | PubTator, text mining | PubMed |
| Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model. | Nat Commun | 2026 | 41922349 | PubTator, text mining | PubMed |
1 to 10 of 2,382
See all 2,382 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2071
GET https://conductscience.org/api/genes/v1/2071/patents?page=2