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Gene · 2071

ERCC3: ERCC excision repair 3, TFIIH core complex helicase subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ERCC3: ERCC excision repair 3, TFIIH core complex helicase subunit. Genes, record 2071. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2071

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Gene

Symbol
ERCC3
HGNC
Name
ERCC excision repair 3, TFIIH core complex helicase subunit
HGNC
NCBI Gene ID
2071
NCBI Gene
HGNC ID
HGNC:3435
HGNC
Ensembl
ENSG00000163161
NCBI Gene
Aliases
BTF2, GTF2H, RAD25, Ssl2, TFIIH, TTD2, XPB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P19447General transcription and DNA repair factor IIH helicase/translocase subunit XPB78252Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445603P19447Espacenet
EP 4464338 A22024-11-20376P19447Espacenet
US 11976334 B22024-05-07141P19447Espacenet
US 11834686 B22023-12-0559P19447Espacenet
US 11680268 B22023-06-20376P19447Espacenet
US 11597924 B22023-03-0750P19447Espacenet
US 11504404 B22022-11-22179P19447Espacenet
US 11446398 B22022-09-2029009P19447Espacenet
JP 2022524081 A2022-04-27131980P19447Espacenet
JP 2021536229 A2021-12-2772P19447Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,695

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleERCC3 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines302025
P30CA008748Cancer Center Support Grant202025
P30CA016672Cancer Center Support Grant202025
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability132025
ZIAAG000753Fanconi Anemia Pathway132025
P30ES010126UNC Center for Environmental Health and Susceptibility112025
ZIASC009144Mechanisms of transcription factor integration at the c-myc promoter102025
P30CA015704Cancer Center Support Grant82025
ZIAAG000752Model Genetic Systems to Study DNA Repair82025
R01ES025987Environmental DNA Lesions and Mutagenesis: Molecular Mechanisms of Lesion Recognition for Repair and Polymerase Bypass72025

1 to 10 of 1,695Source NIH's project files

See all 1,695 nih grants

Papers2,382

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
XPA confers ability of endonucleases to act processively and to incise damaged nucleosomal DNA.Exp Biol Med (Maywood)202642643815PubTator, text miningPubMed
TIP60 promotes chemoresistance by limiting intracellular platinum accumulation and enhancing removal of cisplatin-DNA adducts.J Biol Chem202642463050PubTator, text miningPubMed
Genetic Determinants of T-Cell Homeostasis in Critical Illness: An Exploratory Analysis of Immune Gene Variants and TREC Dynamics.J Pers Med202642346589PubTator, text miningPubMed
Correction to "Imaging-Based High-Content Screening With Clickable Probes Identifies XPB Inhibitors".Angew Chem Int Ed Engl202642338054PubTator, text miningPubMed
RNA polymerase II transcription initiation with and without XPB translocase activity.Commun Biol202642098258PubTator, text miningPubMed
Integrated DNA Repair Capacity and NER Gene Expression for Improving Risk Prediction in Head and Neck Squamous Cell Carcinoma.Curr Med Sci202642081182PubTator, text miningPubMed
Triptolide: A Narrative Review of Its Traditional Use, Derivatives, Pharmacology, Antitumor Effect, and Clinical Applications.Cancers (Basel)202642073523PubTator, text miningPubMed
Genome Sequencing of Undiagnosed European Patients Suspected of Hereditary Cancer: Diagnostic Yield and Identification of Candidate Causative Variants.JCO Precis Oncol202641990296PubTator, text miningPubMed
Chemotherapy with bevacizumab and pembrolizumab followed by radiotherapy for unclassified round cell sarcomas of the gallbladder: A case report and review of literature.Transl Oncol202641956009PubTator, text miningPubMed
Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model.Nat Commun202641922349PubTator, text miningPubMed

1 to 10 of 2,382

See all 2,382 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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