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Gene · 2072

ERCC4: ERCC excision repair 4, endonuclease catalytic subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ERCC4: ERCC excision repair 4, endonuclease catalytic subunit. Genes, record 2072. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2072

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Gene

Symbol
ERCC4
HGNC
Name
ERCC excision repair 4, endonuclease catalytic subunit
HGNC
NCBI Gene ID
2072
NCBI Gene
HGNC ID
HGNC:3436
HGNC
Ensembl
ENSG00000175595
NCBI Gene
Aliases
ERCC11, FANCQ, RAD1, XFEPS, XPF
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92889DNA repair endonuclease XPF91613Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-29634Q92889Espacenet
EP 4641201 A22025-10-294257Q92889Espacenet
JP 2025519096 A2025-06-24634Q92889Espacenet
JP 2025517969 A2025-06-124257Q92889Espacenet
EP 4524569 A22025-03-1924Q92889Espacenet
EP 4464338 A22024-11-20307Q92889Espacenet
JP 2024123008 A2024-09-106125Q92889Espacenet
US 12023339 B22024-07-0224Q92889Espacenet
US 11976334 B22024-05-07142Q92889Espacenet
US 11680268 B22023-06-20307Q92889Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,923

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleERCC4 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines422025
P30CA016672Cancer Center Support Grant332025
P30CA008748Cancer Center Support Grant232025
P30ES010126UNC Center for Environmental Health and Susceptibility192025
R01CA093729Repair of Genome Destabilizing DNA Structures162025
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs162025
P30CA047904Cancer Center Support Grant122025
R35GM118102Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock122025
ZIABC006161DNA Topoisomerases as nuclear and mitochondrial targets of Anticancer Drugs102025
ZIACP010144Clinical Genetic Studies of Familial and Hereditary Cancer Syndromes92025

1 to 10 of 1,923Source NIH's project files

See all 1,923 nih grants

Papers3,434

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness.Nature202642778593PubTator, text miningPubMed
Nanoparticle Co-delivery of Microtubule Inhibitors and Cisplatin Overcomes DNA Repair-Mediated Resistance in Head and Neck Cancer.Mol Cancer Ther202642777141PubTator, text miningPubMed
Rad1-Rad10 uses different interfaces to interact with pathway-specific DNA repair factors.Nucleic Acids Res202642745665PubTator, text miningPubMed
Genetic variation and response to platinum chemotherapy in cancer treatment: a review article.Pharmacogenomics202642725560PubTator, text miningPubMed
Ultramutagenesis through Combined Msh2 Depletion and Proofreading-Deficient DNA Polymerase ε Expression Enhances Small-Molecule Target Identification in Forward Genetic Screens.ACS Chem Biol202642723219PubTator, text miningPubMed
XPA confers ability of endonucleases to act processively and to incise damaged nucleosomal DNA.Exp Biol Med (Maywood)202642643815PubTator, text miningPubMed
Genomic landscape of ERCC alterations in breast and gynecological cancers: implications for targeted therapy and VUS reclassification.Mol Biol Rep202642627456PubTator, text miningPubMed
CRISPR Screening Identifies SMARCAL1 and MRN as Modulators of WRN Dependency in MSI-H Colorectal Cancer.Cancer Res202642484294PubTator, text miningPubMed
Ultramutagenesis through combined Msh2 depletion and proofreading-deficient DNA polymerase ε expression enhances small molecule target identification in forward genetic screens.bioRxiv202642427792PubTator, text miningPubMed
Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.J Cell Biol202642377264PubTator, text miningPubMed

1 to 10 of 3,434

See all 3,434 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2072

GET https://conductscience.org/api/genes/v1/2072/patents?page=2