Gene · 2072
ERCC4: ERCC excision repair 4, endonuclease catalytic subunit
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ERCC4: ERCC excision repair 4, endonuclease catalytic subunit. Genes, record 2072. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2072
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q92889 | DNA repair endonuclease XPF | 916 | 13 | Ensembl, GeneID, HGNC |
Source UniProt
Patents49
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4640849 A2 | 2025-10-29 | 634 | Q92889 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4257 | Q92889 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 634 | Q92889 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4257 | Q92889 | Espacenet |
| EP 4524569 A2 | 2025-03-19 | 24 | Q92889 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 307 | Q92889 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6125 | Q92889 | Espacenet |
| US 12023339 B2 | 2024-07-02 | 24 | Q92889 | Espacenet |
| US 11976334 B2 | 2024-05-07 | 142 | Q92889 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 307 | Q92889 | Espacenet |
1 to 10 of 49
See all 49 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,923
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ERCC4 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 42 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 33 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 23 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 19 | 2025 |
| R01CA093729 | Repair of Genome Destabilizing DNA Structures | 16 | 2025 |
| ZIABC006150 | DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs | 16 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 12 | 2025 |
| R35GM118102 | Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock | 12 | 2025 |
| ZIABC006161 | DNA Topoisomerases as nuclear and mitochondrial targets of Anticancer Drugs | 10 | 2025 |
| ZIACP010144 | Clinical Genetic Studies of Familial and Hereditary Cancer Syndromes | 9 | 2025 |
1 to 10 of 1,923Source NIH's project files
See all 1,923 nih grantsPapers3,434
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness. | Nature | 2026 | 42778593 | PubTator, text mining | PubMed |
| Nanoparticle Co-delivery of Microtubule Inhibitors and Cisplatin Overcomes DNA Repair-Mediated Resistance in Head and Neck Cancer. | Mol Cancer Ther | 2026 | 42777141 | PubTator, text mining | PubMed |
| Rad1-Rad10 uses different interfaces to interact with pathway-specific DNA repair factors. | Nucleic Acids Res | 2026 | 42745665 | PubTator, text mining | PubMed |
| Genetic variation and response to platinum chemotherapy in cancer treatment: a review article. | Pharmacogenomics | 2026 | 42725560 | PubTator, text mining | PubMed |
| Ultramutagenesis through Combined Msh2 Depletion and Proofreading-Deficient DNA Polymerase ε Expression Enhances Small-Molecule Target Identification in Forward Genetic Screens. | ACS Chem Biol | 2026 | 42723219 | PubTator, text mining | PubMed |
| XPA confers ability of endonucleases to act processively and to incise damaged nucleosomal DNA. | Exp Biol Med (Maywood) | 2026 | 42643815 | PubTator, text mining | PubMed |
| Genomic landscape of ERCC alterations in breast and gynecological cancers: implications for targeted therapy and VUS reclassification. | Mol Biol Rep | 2026 | 42627456 | PubTator, text mining | PubMed |
| CRISPR Screening Identifies SMARCAL1 and MRN as Modulators of WRN Dependency in MSI-H Colorectal Cancer. | Cancer Res | 2026 | 42484294 | PubTator, text mining | PubMed |
| Ultramutagenesis through combined Msh2 depletion and proofreading-deficient DNA polymerase ε expression enhances small molecule target identification in forward genetic screens. | bioRxiv | 2026 | 42427792 | PubTator, text mining | PubMed |
| Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1. | J Cell Biol | 2026 | 42377264 | PubTator, text mining | PubMed |
1 to 10 of 3,434
See all 3,434 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2072
GET https://conductscience.org/api/genes/v1/2072/patents?page=2