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Gene · 2073

ERCC5: ERCC excision repair 5, endonuclease

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ERCC5: ERCC excision repair 5, endonuclease. Genes, record 2073. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2073

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Gene

Symbol
ERCC5
HGNC
Name
ERCC excision repair 5, endonuclease
HGNC
NCBI Gene ID
2073
NCBI Gene
HGNC ID
HGNC:3437
HGNC
Ensembl
ENSG00000134899
NCBI Gene
Aliases
COFS3, ERCC5-201, ERCM2, UVDR, XPG, XPGC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P28715DNA excision repair protein ERCC-51,18610Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1919771P28715Espacenet
EP 4641201 A22025-10-2925685P28715Espacenet
JP 2025517969 A2025-06-1225685P28715Espacenet
JP 2025517970 A2025-06-1219771P28715Espacenet
EP 4464338 A22024-11-20382P28715Espacenet
JP 2024123008 A2024-09-106128P28715Espacenet
US 11976334 B22024-05-07143P28715Espacenet
US 11680268 B22023-06-20382P28715Espacenet
US 11597924 B22023-03-0733P28715Espacenet
US 11446398 B22022-09-2029017P28715Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,600

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleERCC5 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines512025
P30CA016672Cancer Center Support Grant252025
P30ES010126UNC Center for Environmental Health and Susceptibility182025
P30CA008748Cancer Center Support Grant152025
R35GM118102Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock142025
R01CA093729Repair of Genome Destabilizing DNA Structures112025
R35CA220430Mesoscale and Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC)102025
R01ES025987Environmental DNA Lesions and Mutagenesis: Molecular Mechanisms of Lesion Recognition for Repair and Polymerase Bypass82025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures82025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant72025

1 to 10 of 1,600Source NIH's project files

See all 1,600 nih grants

Papers2,901

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Ultramutagenesis through Combined Msh2 Depletion and Proofreading-Deficient DNA Polymerase ε Expression Enhances Small-Molecule Target Identification in Forward Genetic Screens.ACS Chem Biol202642723219PubTator, text miningPubMed
XPA confers ability of endonucleases to act processively and to incise damaged nucleosomal DNA.Exp Biol Med (Maywood)202642643815PubTator, text miningPubMed
Controlling scissors during DNA repair of UV light-induced damage.J Cell Biol202642446522PubTator, text miningPubMed
Ultramutagenesis through combined Msh2 depletion and proofreading-deficient DNA polymerase ε expression enhances small molecule target identification in forward genetic screens.bioRxiv202642427792PubTator, text miningPubMed
Association between ERCC5 gene rs17655 polymorphism and the risk of breast cancer: an updated meta-analysis.Environ Health Prev Med202642386575PubTator, text miningPubMed
Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.J Cell Biol202642377264PubTator, text miningPubMed
Prostate Cancer: Etiology, Diagnosis, and Treatment.Serican J Med202642375929PubTator, text miningPubMed
A meta-analysis and expression profiling of DNA repair gene polymorphisms in leukemia.Front Oncol202642109639PubTator, text miningPubMed
Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model.Nat Commun202641922349PubTator, text miningPubMed
Exploration of the mechanism of chemobrain related to neuroinflammation from 1994 to 2023.Clinics (Sao Paulo)202641905326PubTator, text miningPubMed

1 to 10 of 2,901

See all 2,901 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2073

GET https://conductscience.org/api/genes/v1/2073/patents?page=2