Gene · 2073
ERCC5: ERCC excision repair 5, endonuclease
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ERCC5: ERCC excision repair 5, endonuclease. Genes, record 2073. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2073
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P28715 | DNA excision repair protein ERCC-5 | 1,186 | 10 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 19771 | P28715 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 25685 | P28715 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 25685 | P28715 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 19771 | P28715 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 382 | P28715 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6128 | P28715 | Espacenet |
| US 11976334 B2 | 2024-05-07 | 143 | P28715 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 382 | P28715 | Espacenet |
| US 11597924 B2 | 2023-03-07 | 33 | P28715 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 29017 | P28715 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,600
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ERCC5 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 51 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 25 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 18 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 15 | 2025 |
| R35GM118102 | Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock | 14 | 2025 |
| R01CA093729 | Repair of Genome Destabilizing DNA Structures | 11 | 2025 |
| R35CA220430 | Mesoscale and Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC) | 10 | 2025 |
| R01ES025987 | Environmental DNA Lesions and Mutagenesis: Molecular Mechanisms of Lesion Recognition for Repair and Polymerase Bypass | 8 | 2025 |
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 8 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 7 | 2025 |
1 to 10 of 1,600Source NIH's project files
See all 1,600 nih grantsPapers2,901
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Ultramutagenesis through Combined Msh2 Depletion and Proofreading-Deficient DNA Polymerase ε Expression Enhances Small-Molecule Target Identification in Forward Genetic Screens. | ACS Chem Biol | 2026 | 42723219 | PubTator, text mining | PubMed |
| XPA confers ability of endonucleases to act processively and to incise damaged nucleosomal DNA. | Exp Biol Med (Maywood) | 2026 | 42643815 | PubTator, text mining | PubMed |
| Controlling scissors during DNA repair of UV light-induced damage. | J Cell Biol | 2026 | 42446522 | PubTator, text mining | PubMed |
| Ultramutagenesis through combined Msh2 depletion and proofreading-deficient DNA polymerase ε expression enhances small molecule target identification in forward genetic screens. | bioRxiv | 2026 | 42427792 | PubTator, text mining | PubMed |
| Association between ERCC5 gene rs17655 polymorphism and the risk of breast cancer: an updated meta-analysis. | Environ Health Prev Med | 2026 | 42386575 | PubTator, text mining | PubMed |
| Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1. | J Cell Biol | 2026 | 42377264 | PubTator, text mining | PubMed |
| Prostate Cancer: Etiology, Diagnosis, and Treatment. | Serican J Med | 2026 | 42375929 | PubTator, text mining | PubMed |
| A meta-analysis and expression profiling of DNA repair gene polymorphisms in leukemia. | Front Oncol | 2026 | 42109639 | PubTator, text mining | PubMed |
| Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model. | Nat Commun | 2026 | 41922349 | PubTator, text mining | PubMed |
| Exploration of the mechanism of chemobrain related to neuroinflammation from 1994 to 2023. | Clinics (Sao Paulo) | 2026 | 41905326 | PubTator, text mining | PubMed |
1 to 10 of 2,901
See all 2,901 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2073
GET https://conductscience.org/api/genes/v1/2073/patents?page=2