Gene · 2074
ERCC6: ERCC excision repair 6, chromatin remodeling factor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ERCC6: ERCC excision repair 6, chromatin remodeling factor. Genes, record 2074. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2074
On this page
Gene
Proteins2
Reviewed human proteins whose Swiss-Prot entry states the gene.
Patents77
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 175 | Q03468 | Espacenet |
| JP 2026504733 A | 2026-02-09 | 424 | Q03468 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 12206 | P0DP91 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7216 | Q03468 | Espacenet |
| US 12473539 B2 | 2025-11-18 | 324 | Q03468 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 13241 | P0DP91 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7152 | Q03468 | Espacenet |
| US 12435325 B2 | 2025-10-07 | 324 | Q03468 | Espacenet |
| JP 2025529915 A | 2025-09-09 | 285 | Q03468 | Espacenet |
| JP 2025528195 A | 2025-08-26 | 563 | Q03468 | Espacenet |
1 to 10 of 77
See all 77 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,375
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ERCC6 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 19 | 2025 |
| R01GM102362 | Molecular Mechanisms for DNA Damage Processing by Transcription Machinery | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| ZIAAG000723 | ALZHEIMERS RESEARCH PROJECT: DNA repair dysfunction in neurodegeneration and Alzheimer's Disease | 11 | 2025 |
| ZIAAG000741 | Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability | 10 | 2025 |
| R35GM118102 | Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock | 9 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 8 | 2025 |
| P30CA118100 | University of New Mexico Cancer Center Support Grant | 7 | 2025 |
| R01CA093729 | Repair of Genome Destabilizing DNA Structures | 6 | 2025 |
1 to 10 of 1,375Source NIH's project files
See all 1,375 nih grantsPapers2,375
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Unlocking Zenith Electronic State of Ni Sites in Ligand-Engineered COFs for Efficient •O2 --Driven Uranium Photoreduction. | Adv Sci (Weinh) | 2026 | 42801611 | PubTator, text mining | PubMed |
| ERCC6 at the Transcription-Replication Interface: Integration of Transcription-Coupled Repair with Replication Stress Responses. | Int J Mol Sci | 2026 | 42653399 | PubTator, text mining | PubMed |
| Topology Resetting During Transcription-Coupled Nucleotide Excision Repair. | Int J Mol Sci | 2026 | 42653251 | PubTator, text mining | PubMed |
| Surgical correction of severe rigid equinovarus deformity in Cockayne syndrome: perioperative challenges and multidisciplinary management-a case report. | J Surg Case Rep | 2026 | 42634649 | PubTator, text mining | PubMed |
| Divergent somatic mutation patterns among human cerebellar neuron types. | Neuron | 2026 | 42575091 | PubTator, text mining | PubMed |
| Positional Effects of Single-Atom Active Sites in 1D Porphyrinic COFs on Photocatalytic CO2 Reduction. | Angew Chem Int Ed Engl | 2026 | 42531046 | PubTator, text mining | PubMed |
| Fulminant extraneural metastases in MYC-amplified Group 3 medulloblastoma: a pediatric case report. | Childs Nerv Syst | 2026 | 42399488 | PubTator, text mining | PubMed |
| Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations. | J Invest Dermatol | 2026 | 42373067 | PubTator, text mining | PubMed |
| CRISPR/Cas9-mediated editing of ERCC6 in iPSCs: A disease model for Cockayne Syndrome type B. | Stem Cell Res | 2026 | 42349105 | PubTator, text mining | PubMed |
| Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26. | Nat Commun | 2026 | 42342665 | PubTator, text mining | PubMed |
1 to 10 of 2,375
See all 2,375 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2074
GET https://conductscience.org/api/genes/v1/2074/patents?page=2