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ERN1: endoplasmic reticulum to nucleus signaling 1

1 protein, 52 patents, 0 drugs, 0 trials, 5,140 NIH grants and 11,171 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolERN1HGNC
Nameendoplasmic reticulum to nucleus signaling 1HGNC
NCBI Gene ID2081NCBI Gene
HGNC IDHGNC:3449HGNC
EnsemblENSG00000178607NCBI Gene
AliasesIRE1, IRE1P, IRE1a, hIRE1pNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O75460Serine/threonine-protein kinase/endoribonuclease IRE197726Ensembl, GeneID, HGNCUniProt

Patents 52

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1913096O75460Espacenet
EP 4640849 A22025-10-292241O75460Espacenet
EP 4641201 A22025-10-2914767O75460Espacenet
EP 4641202 A22025-10-29790O75460Espacenet
EP 4641203 A22025-10-29452O75460Espacenet
JP 2025147176 A2025-10-064897O75460Espacenet
JP 2025529142 A2025-09-041438O75460Espacenet
JP 2025529142 A2025-09-046293O75460Espacenet
US 12404248 B22025-09-021O75460Espacenet
US 12371689 B22025-07-291438O75460Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5140

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant332,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program242,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)242,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology222,025NIH's project files
P30CA030199Cancer Center Support Grant (CCSG)192,025NIH's project files
P40OD010440Caenorhabditis Genetics Center192,025NIH's project files
R01CA163910Targeting ER stress response in B-cell chronic lymphocytic leukemia192,025NIH's project files
R01DK088199Endoplasmic reticulum stress and intestinal inflammation182,025NIH's project files
R01DK044319Characterization of Mucosal Lymphocytes162,025NIH's project files
R01DK090313A novel CREBH-derived hepatokine regulates triglyceride metabolism152,025NIH's project files

Papers 11171

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825362PubTator, text miningPubMed
42822072PubTator, text miningPubMed
42814397PubTator, text miningPubMed
42813994PubTator, text miningPubMed
42800448PubTator, text miningPubMed
42799139PubTator, text miningPubMed
42797827PubTator, text miningPubMed
42790022PubTator, text miningPubMed
42783759PubTator, text miningPubMed
42782316PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license