ConductScience.org, home

Gene · 2091

FBL: fibrillarin rRNA 2'-O-methyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. FBL: fibrillarin rRNA 2'-O-methyltransferase. Genes, record 2091. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2091

On this page

Gene

Symbol
FBL
HGNC
Name
fibrillarin rRNA 2'-O-methyltransferase
HGNC
NCBI Gene ID
2091
NCBI Gene
HGNC ID
HGNC:3599
HGNC
Ensembl
ENSG00000105202
NCBI Gene
Aliases
FIB, FLRN, Nop1, RNU3IP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22087rRNA 2'-O-methyltransferase fibrillarin32112Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1446201P22087Espacenet
EP 4650780 A22025-11-19522P22087Espacenet
EP 4641201 A22025-10-29371P22087Espacenet
EP 4641202 A22025-10-294339P22087Espacenet
JP 2025517969 A2025-06-12371P22087Espacenet
JP 2025517970 A2025-06-12522P22087Espacenet
KR 1020250017231 A2025-02-044339P22087Espacenet
JP 2023534800 A2023-08-142P22087Espacenet
US 11446398 B22022-09-2031757P22087Espacenet
US 11446398 B22022-09-2031776P22087Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,725

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFBL papersNewest fiscal year
R35GM131687Novel regulatory networks driving human ribosome biogenesis92025
P30CA013148Comprehensive Cancer Center Support Grant82025
P30CA013330Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
P30CA006973Regional Oncology Research Center52025
T32AR048522Multidisciplinary Rheumatology Training Program52025
T32CA009302Leveraging innovative technologies in basic and clinical cancer research52025
P30CA014051Cancer Center Support (Core) Grant42025
P30CA016520Abramson Cancer Center Support Grant42025
P30CA021765Cancer Center Support Grant (CCSG)42025

1 to 10 of 1,725Source NIH's project files

See all 1,725 nih grants

Papers2,899

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
KPNA1/importin α5 localizes to the nucleolus and associates with box C/D snoRNP complexes.Biochem Biophys Res Commun202642659866PubTator, text miningPubMed
Fibrillarin Resists Cellular Senescence Via SIRT1-Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma.Adv Sci (Weinh)202642573012PubTator, text miningPubMed
Nuclear type I myosins actively support nucleolar and nuclear structure and function.Genes Dev202642562576PubTator, text miningPubMed
Identification of RNA binding proteins targeting TP53, RB1 and PTEN in colorectal cancer as potential biomarkers for diagnosis, drug resistance, sensitivity and prognosis.Discov Oncol202642443465PubTator, text miningPubMed
Human respiratory syncytial virus regulates the expression of interferon-stimulated genes through modulation of fibrillarin.Front Cell Infect Microbiol202642064218PubTator, text miningPubMed
Nucleolar expansion: A biomolecular condensate mortality timer.Geromedicine202642016362PubTator, text miningPubMed
Clinical relevance of specific and non-specific autoantibodies in systemic sclerosis without overlap features.Semin Arthritis Rheum202641990462PubTator, text miningPubMed
Uridine metabolism promotes lung adenocarcinoma progression by activating FBL transcription via YBX1.J Transl Med202641987290PubTator, text miningPubMed
Immunoprecipitation-mass spectrometry reveals known and novel (NatC, BCS1L) antinuclear antibodies in rheumatoid arthritis.RMD Open202641963076PubTator, text miningPubMed
ASO therapy rescues NOTCH2NLC GGC repeat expansion-induced genomic damage, 3D chromatin structural abnormalities, and senescence.Nat Commun202641942455PubTator, text miningPubMed

1 to 10 of 2,899

See all 2,899 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2091

GET https://conductscience.org/api/genes/v1/2091/patents?page=2