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ESR1: estrogen receptor 1

1 protein, 225 patents, 56 drugs, 1,396 trials, 26,659 NIH grants and 118,937 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolESR1HGNC
Nameestrogen receptor 1HGNC
NCBI Gene ID2099NCBI Gene
HGNC IDHGNC:3467HGNC
EnsemblENSG00000091831NCBI Gene
AliasesER, ER-alpha, ESR, ESRA, ESTRR, Era, NR3A1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P03372Estrogen receptor595479Ensembl, GeneID, HGNCUniProt

Patents 225

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4820552 A12026-10-141P03372Espacenet
EP 4756030 A12026-06-108P03372Espacenet
JP 2026517821 A2026-06-021P03372Espacenet
JP 2026086503 A2026-05-26119P03372Espacenet
US 12559530 B22026-02-24334P03372Espacenet
JP 2026504440 A2026-02-051P03372Espacenet
EP 4658255 A12025-12-101P03372Espacenet
EP 4658677 A22025-12-101P03372Espacenet
JP 2025147176 A2025-10-0614941P03372Espacenet
JP 2025147176 A2025-10-0616590P03372Espacenet

Drugs 56

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACOLBIFENECHEMBL68055Estrogen receptor modulatorMODULATORChEMBL
AFIMOXIFENECHEMBL489Estrogen receptor modulatorMODULATORChEMBL
ALLYLESTRENOLCHEMBL3185133Estrogen receptor agonistAGONISTChEMBL
AMCENESTRANTCHEMBL4475463Estrogen receptor alpha degraderDEGRADERChEMBL
ARZOXIFENECHEMBL226267Estrogen receptor modulatorMODULATORChEMBL
BAZEDOXIFENECHEMBL46740Estrogen receptor modulatorMODULATORChEMBL
BAZEDOXIFENE ACETATECHEMBL2106615Estrogen receptor modulatorMODULATORChEMBL
BRILANESTRANTCHEMBL3581693Estrogen receptor degraderDEGRADERChEMBL
CAMIZESTRANTCHEMBL4650365Estrogen receptor alpha degraderDEGRADERChEMBL
CHF4227CHEMBL3545355Estrogen receptor modulatorMODULATORChEMBL

Trials 1396

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604571FULVESTRANTPHASE1ClinicalTrials.gov
NCT07604272FULVESTRANTPHASE1ClinicalTrials.gov
NCT07570966FULVESTRANTPHASE1/PHASE2ClinicalTrials.gov
NCT07563595ELACESTRANTClinicalTrials.gov
NCT07558733FULVESTRANTPHASE1/PHASE2ClinicalTrials.gov
NCT07543250FULVESTRANTClinicalTrials.gov
NCT07541079GIREDESTRANTPHASE3ClinicalTrials.gov
NCT07540572FULVESTRANTPHASE1ClinicalTrials.gov
NCT07536763ESTETROLPHASE3ClinicalTrials.gov
NCT07535905TAMOXIFENPHASE2ClinicalTrials.gov

NIH grants 26659

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant9422,025NIH's project files
P30CA008748Cancer Center Support Grant8882,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE3102,025NIH's project files
P50CA058223SPORE in Breast Cancer2902,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant2372,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant2252,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility1932,025NIH's project files
P30CA068485Cancer Center Support Grant1832,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant1822,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant1812,025NIH's project files

Papers 118937

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827403PubTator, text miningPubMed
42826677PubTator, text miningPubMed
42826074PubTator, text miningPubMed
42825662PubTator, text miningPubMed
42824934PubTator, text miningPubMed
42824873PubTator, text miningPubMed
42823511PubTator, text miningPubMed
42823086PubTator, text miningPubMed
42822966PubTator, text miningPubMed
42822006PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license