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Gene · 21

ABCA3: ATP binding cassette subfamily A member 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ABCA3: ATP binding cassette subfamily A member 3. Genes, record 21. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/21

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Gene

Symbol
ABCA3
HGNC
Name
ATP binding cassette subfamily A member 3
HGNC
NCBI Gene ID
21
NCBI Gene
HGNC ID
HGNC:33
HGNC
Ensembl
ENSG00000167972
NCBI Gene
Aliases
ABC-C, ABC3, EST111653, LBM180, SMDP3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99758Phospholipid-transporting ATPase ABCA31,7042Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026509256 A2026-03-1761Q99758Espacenet
JP 2026027383 A2026-02-1825Q99758Espacenet
JP 2026004568 A2026-01-1438362Q99758Espacenet
EP 4641201 A22025-10-293654Q99758Espacenet
JP 2025533754 A2025-10-0926Q99758Espacenet
JP 2025529142 A2025-09-04180Q99758Espacenet
US 12371689 B22025-07-29180Q99758Espacenet
JP 2025517969 A2025-06-123654Q99758Espacenet
JP 2025062604 A2025-04-147597Q99758Espacenet
JP 2024028256 A2024-03-045Q99758Espacenet

1 to 10 of 25

See all 25 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants938

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleABCA3 papersNewest fiscal year
R01HL149853Functional Characterization of ABCA3 Genomic Variants122025
R01HL095993Derivation of lung epithelia from iPS cells for advanced disease modeling82025
P30ES013508Center of Excellence in Environmental Toxicology72025
ZIABC010830Mechanisms of non-classical multidrug resistance in cancer62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)42025
P30CA016672Cancer Center Support Grant42025
T32DE007057Tissue Engineering and Regeneration42025
ZIABC005598Genetic Analysis of the Multidrug Resistance Phenotype in Tumor Cells42025
ZIABC010030Biochemical Analysis of Multidrug Resistance-linked Transport Proteins42025
P30DK054759Precision Medicine Center for Cystic Fibrosis32025

1 to 10 of 938Source NIH's project files

See all 938 nih grants

Papers1,534

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Adulthood interstitial lung disease due to variants in surfactant related genes: A systematic review.Pulmonology202642784242PubTator, text miningPubMed
Masked ABCA3-Related Interstitial Lung Disease in a Neonate With Prenatally Diagnosed Total Anomalous Pulmonary Venous Connection.J Clin Ultrasound202642693532PubTator, text miningPubMed
The Value of Lung Biopsy in Infants up to 3 Months With Diffuse Lung Disease in a Resource-Limited Setting.Can Respir J202642678672PubTator, text miningPubMed
Intratumoral Corynebacterium is associated with phospholipid metabolic reprogramming and spread through air spaces in lung adenocarcinoma.Front Cell Infect Microbiol202642620632PubTator, text miningPubMed
Interstitial Lung Disease in Children: Rare Genetic Variants Beyond Surfactant Dysfunction.Pediatr Pulmonol202642598967PubTator, text miningPubMed
DNA Methylation of Pharmacologic and Leukemia-Related Genes Predicts Clinical Outcomes in Pediatric Acute Myeloid Leukemia.Cancers (Basel)202642588684PubTator, text miningPubMed
Respiratory Outcomes in Children With Neonatal Respiratory Distress Syndrome and Monoallelic ABCA3 Variants.Pediatr Pulmonol202642295024PubTator, text miningPubMed
The Hidden Variant: Intronic ABCA3 Mutation in Lethal Neonatal Interstitial Lung Disease.Pediatr Pulmonol202642295001PubTator, text miningPubMed
Lentiviral-mediated gene complementation to rescue pathogenic ABCA3 variants.Am J Respir Cell Mol Biol202642089300PubTator, text miningPubMed
Long-Term Static Cultivation Alters Lipid Metabolism and Bioenergetic Capacity in A549 Cells.Int J Mol Sci202642074059PubTator, text miningPubMed

1 to 10 of 1,534

See all 1,534 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/21

GET https://conductscience.org/api/genes/v1/21/patents?page=2