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ESR2: estrogen receptor 2

1 protein, 56 patents, 37 drugs, 247 trials, 7,265 NIH grants and 20,067 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolESR2HGNC
Nameestrogen receptor 2HGNC
NCBI Gene ID2100NCBI Gene
HGNC IDHGNC:3468HGNC
EnsemblENSG00000140009NCBI Gene
AliasesER-BETA, ER-beta, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, ODG8NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q92731Estrogen receptor beta53039Ensembl, GeneID, HGNCUniProt

Patents 56

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2025147176 A2025-10-0614942Q92731Espacenet
JP 2025028160 A2025-02-2814942Q92731Espacenet
KR 1020250019204 A2025-02-102Q92731Espacenet
KR 1020250010750 A2025-01-2114942Q92731Espacenet
JP 2024123008 A2024-09-106048Q92731Espacenet
JP 2024109657 A2024-08-1414781Q92731Espacenet
JP 2024045244 A2024-04-0289Q92731Espacenet
US 11446398 B22022-09-2028243Q92731Espacenet
JP 2022524081 A2022-04-27131214Q92731Espacenet
JP 2021536249 A2021-12-2715135Q92731Espacenet

Drugs 37

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACOLBIFENECHEMBL68055Estrogen receptor modulatorMODULATORChEMBL
AFIMOXIFENECHEMBL489Estrogen receptor modulatorMODULATORChEMBL
ALLYLESTRENOLCHEMBL3185133Estrogen receptor agonistAGONISTChEMBL
ARZOXIFENECHEMBL226267Estrogen receptor modulatorMODULATORChEMBL
AUS-131CHEMBL198877Estrogen receptor beta agonistAGONISTChEMBL
BAZEDOXIFENECHEMBL46740Estrogen receptor modulatorMODULATORChEMBL
BAZEDOXIFENE ACETATECHEMBL2106615Estrogen receptor modulatorMODULATORChEMBL
CHF4227CHEMBL3545355Estrogen receptor modulatorMODULATORChEMBL
CHLOROTRIANISENECHEMBL1200761Estrogen receptor beta modulatorMODULATORChEMBL
CR 1447CHEMBL3545092Estrogen receptor beta agonistAGONISTChEMBL

Trials 247

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07536763ESTETROLPHASE3ClinicalTrials.gov
NCT07417397CHLOROTRIANISENEPHASE3ClinicalTrials.gov
NCT07187284CHLOROTRIANISENEPHASE1/PHASE2ClinicalTrials.gov
NCT07061093ESTETROLClinicalTrials.gov
NCT06944145RALOXIFENEPHASE2ClinicalTrials.gov
NCT06900478CHLOROTRIANISENEPHASE2ClinicalTrials.gov
NCT06882876CHLOROTRIANISENEPHASE1ClinicalTrials.gov
NCT06644937CHLOROTRIANISENEPHASE2/PHASE3ClinicalTrials.gov
NCT06602011CHLOROTRIANISENEClinicalTrials.gov
NCT06495515TOREMIFENEPHASE2ClinicalTrials.gov

NIH grants 7265

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
T32ES007326Interdisciplinary Research Training Program in Environmental Health and Toxicology292,025NIH's project files
P01AG026572Perimenopause in Brain Aging and Alzheimer's Disease262,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)262,025NIH's project files
P30CA016672Cancer Center Support Grant242,025NIH's project files
P30CA118100University of New Mexico Cancer Center Support Grant242,025NIH's project files
P30CA008748Cancer Center Support Grant232,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant212,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology212,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant202,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA192,025NIH's project files

Papers 20067

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827403PubTator, text miningPubMed
42811636PubTator, text miningPubMed
42807520PubTator, text miningPubMed
42803302PubTator, text miningPubMed
42800332PubTator, text miningPubMed
42794985PubTator, text miningPubMed
42790685PubTator, text miningPubMed
42787402PubTator, text miningPubMed
42780285PubTator, text miningPubMed
42773388PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license