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Gene · 2101

ESRRA: estrogen related receptor alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ESRRA: estrogen related receptor alpha. Genes, record 2101. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2101

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Gene

Symbol
ESRRA
HGNC
Name
estrogen related receptor alpha
HGNC
NCBI Gene ID
2101
NCBI Gene
HGNC ID
HGNC:3471
HGNC
Ensembl
ENSG00000173153
NCBI Gene
Aliases
ERR1, ERRa, ERRalpha, ESRL1, NR3B1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P11474Steroid hormone receptor ERR14236Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445287P11474Espacenet
JP 2026004568 A2026-01-1445288P11474Espacenet
JP 2025147176 A2025-10-0614943P11474Espacenet
JP 2025028160 A2025-02-2814943P11474Espacenet
KR 1020250010750 A2025-01-2114943P11474Espacenet
JP 2024109657 A2024-08-1414782P11474Espacenet
US 11981931 B22024-05-1411P11474Espacenet
JP 2024519218 A2024-05-09113P11474Espacenet
KR 1020240005837 A2024-01-1270P11474Espacenet
US 11583555 B22023-02-212P11474Espacenet

1 to 10 of 36

See all 36 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,658

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleESRRA papersNewest fiscal year
P20GM103427Nebraska Research Network in Functional Genomics102025
P30CA016672Cancer Center Support Grant72025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant72025
R35CA197589Inducing Proximity: An Emerging Paradigm for New Therapeutic Modalities72025
P30CA016056Roswell Park Cancer Center Support Grant62025
P30CA016058Cancer Center Support Grant62025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant62025
P30DK056341Washington University Nutrition Obesity Research Center62025
R01DK076077Adaptive and maladaptive repair after kidney injury62025
P01CA022443Molecular Biology and Genetics of Human Tumor Viruses52025

1 to 10 of 1,658Source NIH's project files

See all 1,658 nih grants

Papers2,737

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative transcriptomic and regulatory network analysis reveals associations of seven proposed risk genes with immune-related molecular features in Alzheimer's disease.J Alzheimers Dis202642813688PubTator, text miningPubMed
PGC1α-mediated upregulation of PHD2 represses HIF-signaling, limiting prostate cancer progression.Cell Death Differ202642754649PubTator, text miningPubMed
NLR family pyrin domain containing 3-mediated Kupffer cell pyroptosis aggravates ischemia-reperfusion injury after aging donor liver transplantation through CD38-nicotinamide adenine dinucleotide+-sirtuin 1-dependent acetylation of estrogen-related receptor α.
Am J Transplant202642710596PubTator, text miningPubMed
Role of estrogen-related receptor alpha in osteogenic differentiation.Hum Cell202642704564PubTator, text miningPubMed
Estrogen-related receptor α promotes breast cancer cell migration and invasion by activating transforming growth factor β signaling.Anticancer Drugs202642669034PubTator, text miningPubMed
USP16 promotes osteosarcoma progression by stabilizing ESRRA to enhance mitochondrial oxidative phosphorylation.Biochem Biophys Res Commun202642659864PubTator, text miningPubMed
Kaempferol's Therapeutic Applications and Mechanistic Insights in Ocular Diseases: Current Progress, Challenges, and Translational Opportunities.Pharmaceutics202642654113PubTator, text miningPubMed
Recent Advances (2020-2025) in Estrogen and ER-Positive Breast Cancer: Receptor Signaling, Tumor Microenvironment, Endocrine Therapy Resistance and Innovative Treatment Strategies-A Comprehensive Review.
Cancer Manag Res202642634815PubTator, text miningPubMed
ERRα ameliorates osteoarthritis by inhibiting chondrocyte pyroptosis via targeting NF-κBp65.Eur J Pharmacol202642624454PubTator, text miningPubMed
Female chronic social defeat stress (femCSDS) maps synaptic, bioenergetic and metabolic proteome remodeling in the nucleus accumbens (NAc).Front Syst Biol202642614171PubTator, text miningPubMed

1 to 10 of 2,737

See all 2,737 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2101

GET https://conductscience.org/api/genes/v1/2101/patents?page=2