Gene · 211
ALAS1: 5'-aminolevulinate synthase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ALAS1: 5'-aminolevulinate synthase 1. Genes, record 211. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/211
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P13196 | 5-aminolevulinate synthase, non-specific, mitochondrial | 640 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents105
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37233 | P13196 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 37234 | P13196 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 37236 | P13196 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 37237 | P13196 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4604 | P13196 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4174 | P13196 | Espacenet |
| EP 4612154 A1 | 2025-09-10 | 1 | P13196 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4174 | P13196 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4604 | P13196 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 363 | P13196 | Espacenet |
1 to 10 of 105
See all 105 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials4
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04056481 | GIVOSIRAN | ClinicalTrials.gov | ||
| NCT03338816 | GIVOSIRAN | PHASE3 | 2020-02-11 | ClinicalTrials.gov |
| NCT02949830 | GIVOSIRAN | PHASE1/PHASE2 | 2024-03-12 | ClinicalTrials.gov |
| NCT02452372 | GIVOSIRAN | PHASE1 | ClinicalTrials.gov |
NIH grants868
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ALAS1 papers | Newest fiscal year |
|---|---|---|---|
| U54DK110858 | Center for Iron & Heme Disorders at the University of Utah | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| R01DK074797 | Inter-organ signaling in heme metabolism and organismal homeostasis. | 4 | 2025 |
| ZIAHD001602 | Regulation Of Intracellular Iron Metabolism | 4 | 2025 |
| ZIAHD008814 | Mammalian iron-sulfur cluster biogenesis | 4 | 2025 |
| KL2TR001879 | Institutional Career Development Core | 3 | 2025 |
| P30CA093373 | Cancer Center Support Grant P30 | 3 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 3 | 2025 |
| R01CA225958 | Novel bioengineered microRNA therapeutics for lung cancer | 3 | 2025 |
1 to 10 of 868Source NIH's project files
See all 868 nih grantsPapers1,411
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Single-center real-world experience with givosiran for management of acute intermittent porphyria. | Mol Genet Metab | 2026 | 42804985 | PubTator, text mining | PubMed |
| A mitochondrial insertion directs substrate selection and engagement by the protein unfoldase ClpX. | J Biol Chem | 2026 | 42710671 | PubTator, text mining | PubMed |
| Case Report: A Previously Healthy Young Woman With Lethal, Unremitting Metabolic Acidosis: Could a Novel Variant in ALAS2 Be the Culprit? | Case Rep Pathol | 2026 | 42676669 | PubTator, text mining | PubMed |
| Glycine improves boar sperm linear motility by promoting heme biosynthesis to regulate mitochondrial energy metabolism. | Theriogenology | 2026 | 42667783 | PubTator, text mining | PubMed |
| The Role of Cytochrome P450 Holoenzyme Metabolism in the Origin of Neuropathologies. | Int J Mol Sci | 2026 | 42589625 | PubTator, text mining | PubMed |
| An adaptor for feedback regulation of heme biosynthesis by a mitochondrial protease. | Science | 2026 | 42531414 | PubTator, text mining | PubMed |
| Treating a patient with ADP porphyria through suppression of both hepatic and erythroid ALA production. | Orphanet J Rare Dis | 2026 | 42443962 | PubTator, text mining | PubMed |
| Adverse events of givosiran in the treatment of acute hepatic porphyria: a pharmacovigilance study using the FAERS and VigiAccess databases. | Orphanet J Rare Dis | 2026 | 42271396 | PubTator, text mining | PubMed |
| Evening circadian preference as a potential risk factor for cancer-depression comorbidity: a comprehensive analysis from population cohort to molecular insights. | J Adv Res | 2026 | 42248509 | PubTator, text mining | PubMed |
| Single-cell mapping of regulatory DNA-protein interactions. | Cell | 2026 | 42242226 | PubTator, text mining | PubMed |
1 to 10 of 1,411
See all 1,411 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/211
GET https://conductscience.org/api/genes/v1/211/patents?page=2