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Gene · 2118

ETV4: ETS variant transcription factor 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ETV4: ETS variant transcription factor 4. Genes, record 2118. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2118

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Gene

Symbol
ETV4
HGNC
Name
ETS variant transcription factor 4
HGNC
NCBI Gene ID
2118
NCBI Gene
HGNC ID
HGNC:3493
HGNC
Ensembl
ENSG00000175832
NCBI Gene
Aliases
E1A-F, E1AF, PEA3, PEAS3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P43268ETS translocation variant 44843Ensembl, GeneID, HGNC

Source UniProt

Patents75

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025147176 A2025-10-0614953P43268Espacenet
JP 2025032204 A2025-03-1128033P43268Espacenet
JP 2025032204 A2025-03-1128034P43268Espacenet
JP 2025032204 A2025-03-1128037P43268Espacenet
JP 2025028160 A2025-02-2814953P43268Espacenet
KR 1020250010750 A2025-01-2114953P43268Espacenet
EP 4461818 A22024-11-1328033P43268Espacenet
EP 4461818 A22024-11-1328034P43268Espacenet
EP 4461818 A22024-11-1328037P43268Espacenet
JP 2024123008 A2024-09-106068P43268Espacenet

1 to 10 of 75

See all 75 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,841

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleETV4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant472025
P30CA042014Cancer Center Support Grant192025
P30CA016672Cancer Center Support Grant182025
P50CA097186The Pacific Northwest Prostate Cancer SPORE152025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant102025
P50CA092629SPORE in Prostate Cancer102025
P50CA186786Michigan Prostate SPORE 2025-2030102025
R01HD008188Reproductive Hormones - Biological and Molecular Actions92025
P30CA068485Cancer Center Support Grant82025
R01HD007857Sex Hormone Receptor Component And The Cell Genome82025

1 to 10 of 1,841Source NIH's project files

See all 1,841 nih grants

Papers2,714

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Corrigendum to: "FGF19/FGFR4-mediated elevation of ETV4 facilitates hepatocellular carcinoma metastasis by upregulating PD-L1 and CCL2" [J Hepatol (2023) 79(1):109-125; DOI: 10.1016/j.jhep.2023.02.036].
J Hepatol202642716826PubTator, text miningPubMed
Single-cell mapping of tumor-driven macrophage reprogramming via ETV4-MC1R underlies immunotherapy resistance in colorectal cancer.Int J Surg202642682293PubTator, text miningPubMed
Epigenetic modulation of stromal cell states underpins pathological tissue niches in Crohn's disease.Nat Immunol202642587037PubTator, text miningPubMed
Synthesis of Biobased Aliphatic Poly(ester amide)s and Their Thermal, Tensile Properties, and Selective Depolymerization through Transesterification.JACS Au202642529620PubTator, text miningPubMed
Emerging role of ETV4 in colorectal cancer: from molecular mechanisms to clinical implications.Front Oncol202642528596PubTator, text miningPubMed
Systems Biology and Experimental Validation Enable Discovery of MMP9-Centered Networks, Anticancer Activity, and Pharmacodynamic Signature in Non-Small Cell Lung Cancer.Int J Mol Sci202642511800PubTator, text miningPubMed
In silico evaluation of the role of PEA3 subfamily ETS transcription factors in chemoresistance in ovarian cancer.Turk J Med Sci202642499433PubTator, text miningPubMed
Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer.Genome Res202642469015PubTator, text miningPubMed
Transcription factors ETV4 and ETV5 are required for nephron progenitor cell maintenance, distal nephron development and connection to the collecting system.Front Cell Dev Biol202642459831PubTator, text miningPubMed
Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer.bioRxiv202642427750PubTator, text miningPubMed

1 to 10 of 2,714

See all 2,714 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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