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Gene · 2122

MECOM: MDS1 and EVI1 complex locus

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MECOM: MDS1 and EVI1 complex locus. Genes, record 2122. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2122

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Gene

Symbol
MECOM
HGNC
Name
MDS1 and EVI1 complex locus
HGNC
NCBI Gene ID
2122
NCBI Gene
HGNC ID
HGNC:3498
HGNC
Ensembl
ENSG00000085276
NCBI Gene
Aliases
AML1-EVI-1, EVI1, KMT8E, MDS1, MDS1-EVI1, PRDM3, RUSAT2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q03112Histone-lysine N-methyltransferase MECOM1,2301Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2916504Q03112Espacenet
JP 2025147176 A2025-10-0615273Q03112Espacenet
JP 2025517969 A2025-06-1216504Q03112Espacenet
JP 2025028160 A2025-02-2815273Q03112Espacenet
KR 1020250010750 A2025-01-2115273Q03112Espacenet
JP 2024109657 A2024-08-1415112Q03112Espacenet
US 11446398 B22022-09-2049647Q03112Espacenet
JP 2022524081 A2022-04-27152618Q03112Espacenet
JP 2021536249 A2021-12-2715466Q03112Espacenet
JP 2021507703 A2021-02-2515426Q03112Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,148

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMECOM papersNewest fiscal year
P30CA016672Cancer Center Support Grant302025
P30CA021765Cancer Center Support Grant (CCSG)212025
P30CA008748Cancer Center Support Grant182025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal92025
ZIAHL002339Optimization of genetic modification of HSCs in the NHP model and creation of relevant preclinical models of human disease and therapies92025
P30DK063491Diabetes Research Center (DRC)82025
P30CA016058Cancer Center Support Grant62025
P30CA033572Cancer Center Support Grant62025
R24HD000836Laboratory of Developmental Biology62025
ZIAHL006001Framingham Project/Levy62025

1 to 10 of 2,148Source NIH's project files

See all 2,148 nih grants

Papers2,623

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mutant ASXL1 Cooperates with MECOM and BRD4 to Drive Transcriptional Dysregulation in Human Hematopoiesis.Blood202642771583PubTator, text miningPubMed
Successful induction of remission with azacitidine, venetoclax, and dasatinib followed by allogeneic hematopoietic stem cell transplantation in a patient with Philadelphia chromosome-positive mixed phenotype acute leukemia (B/myeloid): a case report.
Front Med (Lausanne)202642746482PubTator, text miningPubMed
Mutational Landscape and Clonal Dynamics in AML Undergoing PTCy Hematopoietic Cell Transplantation.Transplant Cell Ther202642727885PubTator, text miningPubMed
Rare acute myeloid leukemia harboring BCR/ABL1 (P210), AML1-MDS1/EVI1, and AML1/EAP: case report and literature review.Front Oncol202642694067PubTator, text miningPubMed
Structural complexity and mechanistic diversity of MECOM rearrangements in myeloid neoplasms.Pathology202642562659PubTator, text miningPubMed
Optical genome mapping refines diagnosis of high-grade myeloid neoplasms through detection of MECOM rearrangements cryptic to conventional karyotype.Am J Clin Pathol202642551945PubTator, text miningPubMed
[Analysis of Genetic Characteristics and Clinical Efficacy in Pediatric Acute Myeloid Leukemia with NUP98∷KDM5A Fusion Gene Positive].Zhongguo Shi Yan Xue Ye Xue Za Zhi202642544647PubTator, text miningPubMed
A Mecom-Cdk6 toggle switch governs hematopoietic stem-to-multipotent fate transitions via distinct multistable landscapes.bioRxiv202642427749PubTator, text miningPubMed
Knockdown of LINC01234 suppresses radiation-induced bystander cell ferroptosis through the MECOM-MAPK signaling pathway.Sci Rep202642399315PubTator, text miningPubMed
Therapy-related AML with MECOM rearrangement, biallelic TP53 inactivation, and striking nuclear abnormalities.Blood202642390869PubTator, text miningPubMed

1 to 10 of 2,623

See all 2,623 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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