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Gene · 2131

EXT1: exostosin glycosyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EXT1: exostosin glycosyltransferase 1. Genes, record 2131. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2131

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Gene

Symbol
EXT1
HGNC
Name
exostosin glycosyltransferase 1
HGNC
NCBI Gene ID
2131
NCBI Gene
HGNC ID
HGNC:3512
HGNC
Ensembl
ENSG00000182197
NCBI Gene
Aliases
EXT, LGCR, LGS, TRPS2, TTV, ttv
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16394Exostosin-17466Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2910296Q16394Espacenet
JP 2025529142 A2025-09-041461Q16394Espacenet
US 12371689 B22025-07-291461Q16394Espacenet
JP 2025517969 A2025-06-1210296Q16394Espacenet
WO 2025093745 A12025-05-08130Q16394Espacenet
US 12203933 B22025-01-212Q16394Espacenet
JP 2024123008 A2024-09-106148Q16394Espacenet
US 11446398 B22022-09-2029174Q16394Espacenet
US 11400116 B22022-08-0237Q16394Espacenet
JP 2022524081 A2022-04-27132145Q16394Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,014

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEXT1 papersNewest fiscal year
R01AR061758Pathogenic Mechanisms in Hereditary Multiple Exostoses Syndrome132025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)52025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
R35ES031686Environmental Epigenomics and Precision Environmental Health42025
P30CA006973Regional Oncology Research Center32025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant32025
R01EY018868Integrating biomechanical and biochemical signaling in lacrimal gland development32025
T32HG000040University of Michigan Training Program in Genomic Science32025
U19AI135972SARS-CoV adaptations through a Systems Biology Lens (SYBIL)32025

1 to 10 of 1,014Source NIH's project files

See all 1,014 nih grants

Papers1,841

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of a Lactylation-Related Gene Signature and Candidate Biomarkers for Dilated Cardiomyopathy.J Cell Mol Med202642791204PubTator, text miningPubMed
Tumor-associated osteoclasts converge on a matrix-sulfation program across human bone tumors.Front Cell Dev Biol202642787358PubTator, text miningPubMed
EXT1 in cardiomyocytes promotes heparan sulphate-dependent accumulation of macrophage-derived SOD2 to protect against post-myocardial infarction injury.Br J Pharmacol202642764678PubTator, text miningPubMed
Optical genome mapping identifies cryptic balanced chromosomal rearrangements in karyotypically normal couples with recurrent pregnancy loss or adverse pregnancy history.Hum Mol Genet202642762433PubTator, text miningPubMed
MPO-ANCA-associated glomerulonephritis with immune complex deposition and membranous features in a patient with Sjögren's syndrome: a case report.CEN Case Rep202642645684PubTator, text miningPubMed
Prenatal diagnosis of familial 8q24.11q24.12 and 8q24.13 microdeletions encompassing the exon 1 of EXT1 associated with no apparently phenotypic abnormality in the family carrier members.Taiwan J Obstet Gynecol202642642131PubTator, text miningPubMed
Role of EXT Family Enzymes in Heparan Sulfate Biosynthesis.J Histochem Cytochem202642638461PubTator, text miningPubMed
Evolutionary study of oncogenes and tumor suppressor genes in breast carcinoma.J Taibah Univ Med Sci202642633313PubTator, text miningPubMed
Corrigendum to "Deficiency of EXT1 and FGFR3 genes promotes chondrocyte differentiation, leading to the induction of osteochondroma formation" [Bone 192 (2025) 117370].Bone202642613289PubTator, text miningPubMed
High-coverage paleo-genome research identifies a pathogenic mutation on EXT1 in a Qing-period Chinese individual with multiple osteochondromas.Mol Genet Genomics202642501091PubTator, text miningPubMed

1 to 10 of 1,841

See all 1,841 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2131

GET https://conductscience.org/api/genes/v1/2131/patents?page=2