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Gene · 2139

EYA2: EYA transcriptional coactivator and phosphatase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EYA2: EYA transcriptional coactivator and phosphatase 2. Genes, record 2139. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2139

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Gene

Symbol
EYA2
HGNC
Name
EYA transcriptional coactivator and phosphatase 2
HGNC
NCBI Gene ID
2139
NCBI Gene
HGNC ID
HGNC:3520
HGNC
Ensembl
ENSG00000064655
NCBI Gene
Aliases
EAB1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00167Protein phosphatase EYA25387Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026167249 A12026-08-1311O00167Espacenet
JP 2026004568 A2026-01-1445688O00167Espacenet
EP 4641201 A22025-10-295772O00167Espacenet
JP 2025517969 A2025-06-125772O00167Espacenet
US 11446398 B22022-09-2029268O00167Espacenet
JP 2022524081 A2022-04-27132239O00167Espacenet
US 11078247 B22021-08-033738O00167Espacenet
JP 2019054813 A2019-04-11226123O00167Espacenet
JP 2017121241 A2017-07-13226123O00167Espacenet
WO 2016103269 A12016-06-303937O00167Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants463

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEYA2 papersNewest fiscal year
P30CA046934University of Colorado Cancer Center Support Grant102025
P30CA016672Cancer Center Support Grant42025
P30CA054174Mays Cancer Center at UT Health SA32025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits32025
P30CA030199Cancer Center Support Grant (CCSG)22025
P30DK020572Michigan Diabetes Research Center (MDRC)22025
P30DK116074Stanford Diabetes Research Center22025
R01DK064640Transcription factors in kidney development22025
ZIAHG000024Genetic analysis of type II diabetes22025
K12EY022299Michigan Vision Clinician Scientist Development Program12025

1 to 10 of 463Source NIH's project files

See all 463 nih grants

Papers498

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Convergent genetic and structural parameters of cardiovascular disease related insights of post-acute COVID-19.Biochem Biophys Res Commun202642508134PubTator, text miningPubMed
Direct and indirect regulation of SIX1+EYA transcriptional activity by PA2G4, MCRS1, and SOBP.Tissue Cell202642475796PubTator, text miningPubMed
Electrostatic-Driven Nucleobase Discrimination by Covalent Organic Framework Nanosheets for Deoxyribonucleic Acid Methylation Profiling.J Am Chem Soc202642225312PubTator, text miningPubMed
Molecular mechanisms and therapeutic strategies: DNA methylation in pancreatic cancer.Cancer Biol Ther202641879036PubTator, text miningPubMed
Selective inhibition of ALDH1A3 impedes breast cancer growth and metastasis by blocking ALDH1A3-driven transcriptional programs.iScience202641797928PubTator, text miningPubMed
A genome-wide association study identifies EYA2 as a contributing gene for diabetic retinopathy in type 2 diabetes.Commun Med (Lond)202641741574PubTator, text miningPubMed
A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia.bioRxiv202641726865PubTator, text miningPubMed
Aberrant epithelial differentiation may contribute to endometrial polyp formation: insights from single-cell analysis.Syst Biol Reprod Med202641712676PubTator, text miningPubMed
Characterization of ESR1 alterations in patients with breast and gynecologic cancers.Breast Cancer Res202641555446PubTator, text miningPubMed
Targeting Subcellular Organelles in Breast Cancer with Enzyme Induced Self-Assembly: Stimulated Response with Eyes-Absence Enzymes (EYA).Mol Pharm202540947625PubTator, text miningPubMed

1 to 10 of 498

See all 498 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2139

GET https://conductscience.org/api/genes/v1/2139/patents?page=2