Gene · 2139
EYA2: EYA transcriptional coactivator and phosphatase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. EYA2: EYA transcriptional coactivator and phosphatase 2. Genes, record 2139. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2139
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O00167 | Protein phosphatase EYA2 | 538 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026167249 A1 | 2026-08-13 | 11 | O00167 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 45688 | O00167 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5772 | O00167 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5772 | O00167 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 29268 | O00167 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 132239 | O00167 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 3738 | O00167 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 226123 | O00167 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 226123 | O00167 | Espacenet |
| WO 2016103269 A1 | 2016-06-30 | 3937 | O00167 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants463
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | EYA2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA046934 | University of Colorado Cancer Center Support Grant | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 3 | 2025 |
| R01DK093757 | Genetic epidemiology of rare and regulatory variants for metabolic traits | 3 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 2 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 2 | 2025 |
| P30DK116074 | Stanford Diabetes Research Center | 2 | 2025 |
| R01DK064640 | Transcription factors in kidney development | 2 | 2025 |
| ZIAHG000024 | Genetic analysis of type II diabetes | 2 | 2025 |
| K12EY022299 | Michigan Vision Clinician Scientist Development Program | 1 | 2025 |
1 to 10 of 463Source NIH's project files
See all 463 nih grantsPapers498
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Convergent genetic and structural parameters of cardiovascular disease related insights of post-acute COVID-19. | Biochem Biophys Res Commun | 2026 | 42508134 | PubTator, text mining | PubMed |
| Direct and indirect regulation of SIX1+EYA transcriptional activity by PA2G4, MCRS1, and SOBP. | Tissue Cell | 2026 | 42475796 | PubTator, text mining | PubMed |
| Electrostatic-Driven Nucleobase Discrimination by Covalent Organic Framework Nanosheets for Deoxyribonucleic Acid Methylation Profiling. | J Am Chem Soc | 2026 | 42225312 | PubTator, text mining | PubMed |
| Molecular mechanisms and therapeutic strategies: DNA methylation in pancreatic cancer. | Cancer Biol Ther | 2026 | 41879036 | PubTator, text mining | PubMed |
| Selective inhibition of ALDH1A3 impedes breast cancer growth and metastasis by blocking ALDH1A3-driven transcriptional programs. | iScience | 2026 | 41797928 | PubTator, text mining | PubMed |
| A genome-wide association study identifies EYA2 as a contributing gene for diabetic retinopathy in type 2 diabetes. | Commun Med (Lond) | 2026 | 41741574 | PubTator, text mining | PubMed |
| A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia. | bioRxiv | 2026 | 41726865 | PubTator, text mining | PubMed |
| Aberrant epithelial differentiation may contribute to endometrial polyp formation: insights from single-cell analysis. | Syst Biol Reprod Med | 2026 | 41712676 | PubTator, text mining | PubMed |
| Characterization of ESR1 alterations in patients with breast and gynecologic cancers. | Breast Cancer Res | 2026 | 41555446 | PubTator, text mining | PubMed |
| Targeting Subcellular Organelles in Breast Cancer with Enzyme Induced Self-Assembly: Stimulated Response with Eyes-Absence Enzymes (EYA). | Mol Pharm | 2025 | 40947625 | PubTator, text mining | PubMed |
1 to 10 of 498
See all 498 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2139
GET https://conductscience.org/api/genes/v1/2139/patents?page=2