ConductScience.org, home

Gene · 2145

EZH1: enhancer of zeste 1 polycomb repressive complex 2 subunit

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. EZH1: enhancer of zeste 1 polycomb repressive complex 2 subunit. Genes, record 2145. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2145

On this page

Gene

Symbol
EZH1
HGNC
Name
enhancer of zeste 1 polycomb repressive complex 2 subunit
HGNC
NCBI Gene ID
2145
NCBI Gene
HGNC ID
HGNC:3526
HGNC
Ensembl
ENSG00000108799
NCBI Gene
Aliases
KIAA0388, KMT6B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92800Histone-lysine N-methyltransferase EZH17474Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445017Q92800Espacenet
EP 4650780 A22025-11-1913299Q92800Espacenet
EP 4641201 A22025-10-2915106Q92800Espacenet
JP 2025147176 A2025-10-0614959Q92800Espacenet
JP 2025517969 A2025-06-1215106Q92800Espacenet
JP 2025517970 A2025-06-1213299Q92800Espacenet
JP 2025028160 A2025-02-2814959Q92800Espacenet
KR 1020250010750 A2025-01-2114959Q92800Espacenet
US 12178854 B22024-12-311Q92800Espacenet
JP 2024109657 A2024-08-1414798Q92800Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,102

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEZH1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant252025
P30CA016086Cancer Center Support Grant122025
P30CA016672Cancer Center Support Grant72025
P30CA016087Cancer Center Support Grant52025
R01CA199652Repression via Facultative Heterochromatin52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
P30AI027763UCSF-Bay Area Center for AIDS Research32025
P30CA006973Regional Oncology Research Center32025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA016058Cancer Center Support Grant32025

1 to 10 of 1,102Source NIH's project files

See all 1,102 nih grants

Papers1,378

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exploiting an epigenetic resistance mechanism to PI3-kinase inhibition in leukemic stem cells.Leukemia202642806054PubTator, text miningPubMed
Biallelic EZH1 Nonsense Novel Variant in Two Siblings with Neurodevelopmental Disorder and Central Precocious Puberty: A Case Report from a Consanguineous Saudi Family.Int J Mol Sci202642653090PubTator, text miningPubMed
Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin.Mol Cell202642398503PubTator, text miningPubMed
Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2-Selective Small Molecule Inhibitor.Adv Sci (Weinh)202642314051PubTator, text miningPubMed
Impaired bone matrix turnover with selective small bone fragility in a child with TENT5A-associated osteogenesis imperfecta.JBMR Plus202641908159PubTator, text miningPubMed
RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition.Cell Death Dis202641888518PubTator, text miningPubMed
3D Soft Hydrogels Induce Human Mesenchymal Stem Cells "Deep" Quiescence.Adv Healthc Mater202641834288PubTator, text miningPubMed
Combinational Inhibition of the eIF4F Complex, AKT1, and EZH2 Enhances Anticancer Effects in BRAFV600E Mutant A375 Melanoma Cells.Oncol Res202641799498PubTator, text miningPubMed
Circular RNAs in sepsis-induced acute lung injury: emerging mechanisms and therapeutic potential.Front Immunol202641789098PubTator, text miningPubMed
Impact of Co-Mutations and Genetic Variations on Malignancy Risk in RAS-Positive Indeterminate Thyroid Nodules: an Institutional Experience.Endocr Pathol202641784850PubTator, text miningPubMed

1 to 10 of 1,378

See all 1,378 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2145

GET https://conductscience.org/api/genes/v1/2145/patents?page=2