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EZH2: enhancer of zeste 2 polycomb repressive complex 2 subunit

1 protein, 101 patents, 3 drugs, 51 trials, 9,708 NIH grants and 26,284 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEZH2HGNC
Nameenhancer of zeste 2 polycomb repressive complex 2 subunitHGNC
NCBI Gene ID2146NCBI Gene
HGNC IDHGNC:3527HGNC
EnsemblENSG00000106462NCBI Gene
AliasesENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q15910Histone-lysine N-methyltransferase EZH274641Ensembl, GeneID, HGNCUniProt

Patents 101

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445021Q15910Espacenet
EP 4641201 A22025-10-2916798Q15910Espacenet
EP 4641202 A22025-10-297089Q15910Espacenet
JP 2025147176 A2025-10-0614960Q15910Espacenet
WO 2025184429 A12025-09-0459Q15910Espacenet
JP 2025517969 A2025-06-1216798Q15910Espacenet
JP 2025028160 A2025-02-2814960Q15910Espacenet
KR 1020250017231 A2025-02-047089Q15910Espacenet
KR 1020250010750 A2025-01-2114960Q15910Espacenet
KR 1020250007688 A2025-01-141Q15910Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
GSK2816126CHEMBL3287735Histone-lysine N-methyltransferase EZH2 inhibitorINHIBITORChEMBL
TAZEMETOSTATCHEMBL3414621Histone-lysine N-methyltransferase EZH2 inhibitorINHIBITORChEMBL
TAZEMETOSTAT HYDROBROMIDECHEMBL4594260Histone-lysine N-methyltransferase EZH2 inhibitorINHIBITORChEMBL

Trials 51

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07407283TAZEMETOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT07209163TAZEMETOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT06824701TAZEMETOSTATPHASE1ClinicalTrials.gov
NCT06692452TAZEMETOSTATPHASE2ClinicalTrials.gov
NCT06575686TAZEMETOSTATPHASE2ClinicalTrials.gov
NCT06242834TAZEMETOSTATPHASE2ClinicalTrials.gov
NCT06068881TAZEMETOSTATPHASE2ClinicalTrials.gov
NCT05994235TAZEMETOSTATPHASE2ClinicalTrials.gov
NCT05983965TAZEMETOSTATPHASE1ClinicalTrials.gov
NCT05934838TAZEMETOSTATPHASE1ClinicalTrials.gov

NIH grants 9708

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant3042,025NIH's project files
P30CA016672Cancer Center Support Grant2712,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028522,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)512,025NIH's project files
P30CA006973Regional Oncology Research Center472,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program462,025NIH's project files
P30CA016058Cancer Center Support Grant432,025NIH's project files
P30CA016086Cancer Center Support Grant432,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant382,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center372,025NIH's project files

Papers 26284

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825516PubTator, text miningPubMed
42817718PubTator, text miningPubMed
42815266PubTator, text miningPubMed
42809184PubTator, text miningPubMed
42807872PubTator, text miningPubMed
42806054PubTator, text miningPubMed
42800942PubTator, text miningPubMed
42800881PubTator, text miningPubMed
42797527PubTator, text miningPubMed
42797522PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license