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F2: coagulation factor II, thrombin

1 protein, 213 patents, 14 drugs, 132 trials, 20,081 NIH grants and 93,623 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolF2HGNC
Namecoagulation factor II, thrombinHGNC
NCBI Gene ID2147NCBI Gene
HGNC IDHGNC:3535HGNC
EnsemblENSG00000180210NCBI Gene
AliasesPT, RPRGL2, THPH1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00734Prothrombin622477Ensembl, GeneID, HGNCUniProt

Patents 213

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12560619 B22026-02-2482P00734Espacenet
JP 2025541179 A2025-12-1819P00734Espacenet
EP 4650780 A22025-11-194564P00734Espacenet
JP 2025169942 A2025-11-14893P00734Espacenet
EP 4641201 A22025-10-294115P00734Espacenet
EP 4630459 A12025-10-1519P00734Espacenet
JP 2025147176 A2025-10-064965P00734Espacenet
JP 2025532862 A2025-10-0323P00734Espacenet
JP 2025529142 A2025-09-046310P00734Espacenet
US 12371689 B22025-07-296310P00734Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ANTITHROMBIN ALFACHEMBL1201554Thrombin inhibitorINHIBITORChEMBL
ARGATROBANCHEMBL1166Thrombin inhibitorINHIBITORChEMBL
ATECEGATRAN METOXILCHEMBL4297593Thrombin inhibitorINHIBITORChEMBL
BIVALIRUDINCHEMBL5314348Thrombin inhibitorINHIBITORChEMBL
DABIGATRANCHEMBL48361Thrombin inhibitorINHIBITORChEMBL
DABIGATRAN ETEXILATECHEMBL539697Thrombin inhibitorINHIBITORChEMBL
DABIGATRAN ETEXILATE MESYLATECHEMBL1615369Thrombin inhibitorINHIBITORChEMBL
DEFIBROTIDECHEMBL2108396Thrombin antagonistANTAGONISTChEMBL
DESIRUDINCHEMBL1201662Thrombin inhibitorINHIBITORChEMBL
ICHORCUMABCHEMBL4298002Thrombin inhibitorINHIBITORChEMBL

Trials 132

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07499037ARGATROBANPHASE2ClinicalTrials.gov
NCT07316270DABIGATRANClinicalTrials.gov
NCT07139314DABIGATRANClinicalTrials.gov
NCT07139301DABIGATRANClinicalTrials.gov
NCT07094087PROTHROMBIN COMPLEX CONCENTRATEPHASE3ClinicalTrials.gov
NCT06884384DABIGATRANClinicalTrials.gov
NCT06818279DABIGATRANPHASE2/PHASE3ClinicalTrials.gov
NCT06792643BIVALIRUDINPHASE2ClinicalTrials.gov
NCT06285942DABIGATRANClinicalTrials.gov
NCT06144866DABIGATRANClinicalTrials.gov

NIH grants 20081

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL049413Structural basis of prothrombin activation1242,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI822,025NIH's project files
T32GM008315Mechanisms of Trauma-Induced Coagulopathy732,025NIH's project files
P30CA008748Cancer Center Support Grant692,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award542,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)492,025NIH's project files
R01HL101917Protease Activated Receptor and Thrombomodulin Signaling by coagulation proteases472,025NIH's project files
T32HL007149Research Training in Hematology at UNC Chapel Hill442,025NIH's project files
P30CA016672Cancer Center Support Grant422,025NIH's project files
R01HL045638Programming of PMN host-defense function during transendothelial migration362,025NIH's project files

Papers 93623

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827462PubTator, text miningPubMed
42827284PubTator, text miningPubMed
42825136PubTator, text miningPubMed
42821743PubTator, text miningPubMed
42821140PubTator, text miningPubMed
42820122PubTator, text miningPubMed
42812102PubTator, text miningPubMed
42810474PubTator, text miningPubMed
42809655PubTator, text miningPubMed
42808109PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license