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F2R: coagulation factor II thrombin receptor

1 protein, 63 patents, 4 drugs, 9 trials, 7,622 NIH grants and 15,584 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolF2RHGNC
Namecoagulation factor II thrombin receptorHGNC
NCBI Gene ID2149NCBI Gene
HGNC IDHGNC:3537HGNC
EnsemblENSG00000181104NCBI Gene
AliasesCF2R, HTR, PAR-1, PAR1, TRNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P25116Proteinase-activated receptor 142513Ensembl, GeneID, HGNCUniProt

Patents 63

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441708P25116Espacenet
EP 4650780 A22025-11-195367P25116Espacenet
EP 4641201 A22025-10-294956P25116Espacenet
EP 4641202 A22025-10-29286P25116Espacenet
EP 4641203 A22025-10-29165P25116Espacenet
JP 2025147176 A2025-10-064968P25116Espacenet
JP 2025529142 A2025-09-041465P25116Espacenet
JP 2025529142 A2025-09-046311P25116Espacenet
US 12371689 B22025-07-291465P25116Espacenet
US 12371689 B22025-07-296311P25116Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATOPAXARCHEMBL2103856Proteinase-activated receptor 1 antagonistANTAGONISTChEMBL
PZ-128CHEMBL4297323Proteinase-activated receptor 1 inhibitorINHIBITORChEMBL
VORAPAXARCHEMBL493982Proteinase-activated receptor 1 antagonistANTAGONISTChEMBL
VORAPAXAR SULFATECHEMBL2107386Proteinase-activated receptor 1 antagonistANTAGONISTChEMBL

Trials 9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02561000PZ-128PHASE22021-03-09ClinicalTrials.gov
NCT02545933VORAPAXARPHASE42020-08-25ClinicalTrials.gov
NCT02394730VORAPAXARPHASE1/PHASE22019-02-28ClinicalTrials.gov
NCT01806077PZ-128PHASE1ClinicalTrials.gov
NCT00684515VORAPAXARPHASE22014-07-29ClinicalTrials.gov
NCT00619164ATOPAXARPHASE2ClinicalTrials.gov
NCT00548587ATOPAXARPHASE2ClinicalTrials.gov
NCT00540670ATOPAXARPHASE2ClinicalTrials.gov
NCT00312052ATOPAXARPHASE2ClinicalTrials.gov

NIH grants 7622

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant382,025NIH's project files
P30CA008748Cancer Center Support Grant322,025NIH's project files
R01HL101917Protease Activated Receptor and Thrombomodulin Signaling by coagulation proteases292,025NIH's project files
R01HL049413Structural basis of prothrombin activation262,025NIH's project files
R01HL142975Regulation of Protein C Pathways192,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award192,025NIH's project files
ZIAHD001901Molecular mechanism of thyroid hormone receptor function during metamorphosis182,025NIH's project files
ZIABC008752Thyroid Hormone Nuclear Receptors in Health and Disease172,025NIH's project files
P30CA056036Translational Research in Cancer142,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program132,025NIH's project files

Papers 15584

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42811902PubTator, text miningPubMed
42810688PubTator, text miningPubMed
42778016PubTator, text miningPubMed
42734502PubTator, text miningPubMed
42732865PubTator, text miningPubMed
42727264PubTator, text miningPubMed
42712377PubTator, text miningPubMed
42706545PubTator, text miningPubMed
42694888PubTator, text miningPubMed
42659800PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license