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Gene · 215

ABCD1: ATP binding cassette subfamily D member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ABCD1: ATP binding cassette subfamily D member 1. Genes, record 215. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/215

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Gene

Symbol
ABCD1
HGNC
Name
ATP binding cassette subfamily D member 1
HGNC
NCBI Gene ID
215
NCBI Gene
HGNC ID
HGNC:61
HGNC
Ensembl
ENSG00000101986
NCBI Gene
Aliases
ABC42, ALD, ALDP, AMN, adrenoleukodystrophy
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P33897ATP-binding cassette sub-family D member 174514Ensembl, GeneID, HGNC

Source UniProt

Patents47

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21342P33897Espacenet
JP 2026004568 A2026-01-1438444P33897Espacenet
EP 4650780 A22025-11-19415P33897Espacenet
EP 4641201 A22025-10-29287P33897Espacenet
JP 2025529142 A2025-09-04207P33897Espacenet
WO 2025181336 A12025-09-0473P33897Espacenet
US 12371689 B22025-07-29207P33897Espacenet
JP 2025517969 A2025-06-12287P33897Espacenet
JP 2025517970 A2025-06-12415P33897Espacenet
JP 2025062604 A2025-04-147770P33897Espacenet

1 to 10 of 47

See all 47 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ELIVALDOGENE AUTOTEMCELCHEMBL4594333ABCD1 exogenous geneEXOGENOUS GENE

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants933

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleABCD1 papersNewest fiscal year
U54NS115052Global Leukodystrophy Initiative Clinical Trials Network (GLIA- CTN)52025
P30CA008748Cancer Center Support Grant42025
P30CA077598Cancer Center Support Grant42025
P50HD103538Intellectual and Developmental Disabilities Research Centers42025
R01NS072248Genome Studies in Hereditary Spastic Paraplegia- Beyond the Exome42025
K23NS118044Leveraging Myelin-Sensitive Imaging to Predict Early Lesion Pathogenesis in Cerebral Adrenoleukodystrophy32025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions32025
P30CA006973Regional Oncology Research Center32025
P30CA068485Cancer Center Support Grant32025
UH3OD023318Atlanta ECHO Pediatric Cohort32025

1 to 10 of 933Source NIH's project files

See all 933 nih grants

Papers2,145

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Letter to the Editor from Erdoğan Özbuğday and Karakurt: "Primary adrenal insufficiency resulting in diagnosis of rare ABCD1 pathogenic variant in X-linked adrenoleukodystrophy".JCEM Case Rep202642798852PubTator, text miningPubMed
A Systematic Review of Positron Emission Tomography (PET) in X-Linked Adrenoleukodystrophy: Beyond Structural MRI.Am J Med Genet A202642798143PubTator, text miningPubMed
Effects of combined nutritional interventions on the natural history of X-linked adrenoleukodystrophy in female carriers.J Neuroendocrinol202642767939PubTator, text miningPubMed
Longitudinal Clinical Progression in X-Linked Adrenoleukodystrophy: The AMNL Scoring System.Ann Child Neurol Soc202642751575PubTator, text miningPubMed
ABCD1-Related Disease Presenting as an Upper Motor Neuron-Predominant Amyotrophic Lateral Sclerosis Mimic in a Colombian Female Heterozygote: A Case Report.Cureus202642746497PubTator, text miningPubMed
Multimodal quantitative MRI finds early brain changes in asymptomatic X-linked adrenoleukodystrophy.Brain Commun202642712783PubTator, text miningPubMed
Expanding the ABCD1 mutation spectrum: a novel variant in X-linked adrenomyeloneuropathy.Neurol Sci202642603216PubTator, text miningPubMed
The complex lipidome as a driver of tissue-specific pathology in adrenoleukodystrophy.Mol Neurodegener202642469918PubTator, text miningPubMed
Disease Outcomes in Boys with ABCD1 Variants Identified by Newborn Screening for X-ALD.medRxiv202642428107PubTator, text miningPubMed
Cerebral X-Linked Adrenoleukodystrophy Associated with Hemophilia A: A Case Report.Horm Res Paediatr202642328992PubTator, text miningPubMed

1 to 10 of 2,145

See all 2,145 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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