ConductScience.org, home

Library / Genes

F3: coagulation factor III, tissue factor

1 protein, 130 patents, 1 drug, 7 trials, 15,429 NIH grants and 37,943 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolF3HGNC
Namecoagulation factor III, tissue factorHGNC
NCBI Gene ID2152NCBI Gene
HGNC IDHGNC:3541HGNC
EnsemblENSG00000117525NCBI Gene
AliasesCD142, TF, TFANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P13726Tissue factor29554Ensembl, GeneID, HGNCUniProt

Patents 130

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026219983 A12026-10-229P13726Espacenet
JP 2026076267 A2026-05-11809P13726Espacenet
US 12540197 B22026-02-031P13726Espacenet
JP 2026503880 A2026-02-0212P13726Espacenet
WO 2026017877 A12026-01-2210P13726Espacenet
EP 4650780 A22025-11-196080P13726Espacenet
JP 2025169942 A2025-11-14896P13726Espacenet
JP 2025530129 A2025-09-11175P13726Espacenet
EP 4612275 A22025-09-1012P13726Espacenet
JP 2025529142 A2025-09-041469P13726Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TISOTUMAB VEDOTINCHEMBL4297841Coagulation factor III binding agentBINDING AGENTChEMBL

Trials 7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06952660TISOTUMAB VEDOTINPHASE4ClinicalTrials.gov
NCT04697628TISOTUMAB VEDOTINPHASE32024-08-09ClinicalTrials.gov
NCT03913741TISOTUMAB VEDOTINPHASE1/PHASE2ClinicalTrials.gov
NCT03786081TISOTUMAB VEDOTINPHASE1/PHASE2ClinicalTrials.gov
NCT03657043TISOTUMAB VEDOTINPHASE22023-05-06ClinicalTrials.gov
NCT03485209TISOTUMAB VEDOTINPHASE2ClinicalTrials.gov
NCT03438396TISOTUMAB VEDOTINPHASE22021-11-04ClinicalTrials.gov

NIH grants 15429

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1162,025NIH's project files
P30CA016672Cancer Center Support Grant672,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI392,025NIH's project files
P30CA016058Cancer Center Support Grant372,025NIH's project files
R01HL068835Characterization of an isoform specific anticoagulant function of TFPI-alpha332,025NIH's project files
T32HL007149Research Training in Hematology at UNC Chapel Hill332,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award322,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)302,025NIH's project files
P30CA091842Cancer Center Support Grant282,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant272,025NIH's project files

Papers 37943

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827462PubTator, text miningPubMed
42825136PubTator, text miningPubMed
42818338PubTator, text miningPubMed
42818071PubTator, text miningPubMed
42814899PubTator, text miningPubMed
42812752PubTator, text miningPubMed
42812102PubTator, text miningPubMed
42794639PubTator, text miningPubMed
42783079PubTator, text miningPubMed
42782790PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license