ConductScience.org, home

Library / Genes

F5: coagulation factor V

1 protein, 89 patents, 1 drug, 17 trials, 4,780 NIH grants and 21,407 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolF5HGNC
Namecoagulation factor VHGNC
NCBI Gene ID2153NCBI Gene
HGNC IDHGNC:3542HGNC
EnsemblENSG00000198734NCBI Gene
AliasesFVL, PCCF, RPRGL1, THPH2, fVNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P12259Coagulation factor V2,22418Ensembl, GeneID, HGNCUniProt

Patents 89

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21391P12259Espacenet
JP 2025172069 A2025-11-20645P12259Espacenet
EP 4650780 A22025-11-198300P12259Espacenet
EP 4640849 A22025-10-291251P12259Espacenet
EP 4641201 A22025-10-298488P12259Espacenet
EP 4641203 A22025-10-29239P12259Espacenet
JP 2025147176 A2025-10-064972P12259Espacenet
JP 2025529142 A2025-09-046313P12259Espacenet
US 12371689 B22025-07-296313P12259Espacenet
JP 2025519096 A2025-06-241251P12259Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DROTRECOGIN ALFA (ACTIVATED)CHEMBL2109065Coagulation factor V inhibitorINHIBITORChEMBL

Trials 17

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02843685DROTRECOGIN ALFA (ACTIVATED)ClinicalTrials.gov
NCT01411670DROTRECOGIN ALFA (ACTIVATED)PHASE2ClinicalTrials.gov
NCT01227187DROTRECOGIN ALFA (ACTIVATED)PHASE22022-02-03ClinicalTrials.gov
NCT00943267DROTRECOGIN ALFA (ACTIVATED)ClinicalTrials.gov
NCT00625209DROTRECOGIN ALFA (ACTIVATED)PHASE3ClinicalTrials.gov
NCT00604214DROTRECOGIN ALFA (ACTIVATED)PHASE32012-09-18ClinicalTrials.gov
NCT00568893DROTRECOGIN ALFA (ACTIVATED)PHASE4ClinicalTrials.gov
NCT00568737DROTRECOGIN ALFA (ACTIVATED)PHASE3ClinicalTrials.gov
NCT00533546DROTRECOGIN ALFA (ACTIVATED)PHASE22016-10-24ClinicalTrials.gov
NCT00386425DROTRECOGIN ALFA (ACTIVATED)PHASE22010-12-16ClinicalTrials.gov

NIH grants 4780

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant242,025NIH's project files
R01HL068835Characterization of an isoform specific anticoagulant function of TFPI-alpha182,025NIH's project files
ZIABC010301Development of Recombinant Toxins to Treat Hematologic Malignancies182,025NIH's project files
P30CA008748Cancer Center Support Grant152,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI152,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award152,025NIH's project files
ZIABC010891Development of antibody engineering-based cancer therapies142,025NIH's project files
P30CA016042Cancer Center Support Grant132,025NIH's project files
R01HL049413Structural basis of prothrombin activation132,025NIH's project files
P01HL139420Hemostasis and Thrombosis: Chemistry, Biology and Physiology112,025NIH's project files

Papers 21407

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821973PubTator, text miningPubMed
42807612PubTator, text miningPubMed
42802432PubTator, text miningPubMed
42789805PubTator, text miningPubMed
42777205PubTator, text miningPubMed
42766054PubTator, text miningPubMed
42761862PubTator, text miningPubMed
42758238PubTator, text miningPubMed
42754457PubTator, text miningPubMed
42749602PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license