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F7: coagulation factor VII

1 protein, 128 patents, 6 drugs, 62 trials, 2,412 NIH grants and 10,037 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolF7HGNC
Namecoagulation factor VIIHGNC
NCBI Gene ID2155NCBI Gene
HGNC IDHGNC:3544HGNC
EnsemblENSG00000057593NCBI Gene
AliasesSPCANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08709Coagulation factor VII466114Ensembl, GeneID, HGNCUniProt

Patents 128

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4704876 A22026-03-111P08709Espacenet
US 12560619 B22026-02-24101P08709Espacenet
EP 4650780 A22025-11-199654P08709Espacenet
JP 2025169942 A2025-11-14904P08709Espacenet
EP 4641201 A22025-10-299911P08709Espacenet
JP 2025147176 A2025-10-064976P08709Espacenet
JP 2025532862 A2025-10-0348P08709Espacenet
JP 2025529142 A2025-09-046314P08709Espacenet
US 12371689 B22025-07-296314P08709Espacenet
JP 2025517969 A2025-06-129911P08709Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COAGULATION FACTOR VII HUMANCHEMBL6068490Coagulation factor VII exogenous proteinEXOGENOUS PROTEINChEMBL
EPTACOG ALFA (ACTIVATED)CHEMBL2108334Coagulation factor VII exogenous proteinEXOGENOUS PROTEINChEMBL
EPTACOG ALFA PEGOL (ACTIVATED)CHEMBL2108292Coagulation factor VII exogenous proteinEXOGENOUS PROTEINChEMBL
EPTACOG BETA (ACTIVATED)CHEMBL5315078Coagulation factor VII exogenous proteinEXOGENOUS PROTEINChEMBL
PCI-27483CHEMBL4297315Coagulation factor VII inhibitorINHIBITORChEMBL
PROTHROMBIN COMPLEX CONCENTRATECHEMBL6068614Coagulation factor VII exogenous proteinEXOGENOUS PROTEINChEMBL

Trials 62

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07227246EPTACOG ALFA (ACTIVATED)PHASE3ClinicalTrials.gov
NCT07094087PROTHROMBIN COMPLEX CONCENTRATEPHASE3ClinicalTrials.gov
NCT05568888PROTHROMBIN COMPLEX CONCENTRATEPHASE32025-11-10ClinicalTrials.gov
NCT05523297PROTHROMBIN COMPLEX CONCENTRATEPHASE32025-08-15ClinicalTrials.gov
NCT05298826EPTACOG ALFA (ACTIVATED)ClinicalTrials.gov
NCT04789954EPTACOG ALFA (ACTIVATED)EARLY_PHASE1ClinicalTrials.gov
NCT04723979EPTACOG ALFA (ACTIVATED)ClinicalTrials.gov
NCT04647227EPTACOG ALFA (ACTIVATED)PHASE4ClinicalTrials.gov
NCT04563520EPTACOG ALFA (ACTIVATED)PHASE3ClinicalTrials.gov
NCT04444856EPTACOG ALFA (ACTIVATED)ClinicalTrials.gov

NIH grants 2412

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI182,025NIH's project files
T32HL007149Research Training in Hematology at UNC Chapel Hill142,025NIH's project files
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal102,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award102,025NIH's project files
R01HL068835Characterization of an isoform specific anticoagulant function of TFPI-alpha92,025NIH's project files
P30DK063491Diabetes Research Center (DRC)82,025NIH's project files
P30CA016359Cancer Center Support Grant72,025NIH's project files
T32GM008315Mechanisms of Trauma-Induced Coagulopathy72,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition72,025NIH's project files
P30AG024827Pittsburgh Older Americans Independence Center52,025NIH's project files

Papers 10037

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42717812PubTator, text miningPubMed
42699214PubTator, text miningPubMed
42696556PubTator, text miningPubMed
42680516PubTator, text miningPubMed
42674901PubTator, text miningPubMed
42665231PubTator, text miningPubMed
42648366PubTator, text miningPubMed
42643720PubTator, text miningPubMed
42631282PubTator, text miningPubMed
42608066PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license